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On its surface, I also both instinctively want to say things like this ("it's not depression"), and also find it strange when I see others say things like this. But I think it's because the meaning when this is said is somewhat ambiguous. The person with ME/CFS is saying "What I have is...

Screenshots of the data from the full body scans with the TSPO tracer: 34 year old case and 36 year old control 51 year old case and 50 year old control Edit: Added labels above PET images.

OpenAI (makers of ChatGPT) mentioned Derya Unutmaz and quoted his tweet about using AI for ME/CFS research. https://twitter-thread.com/t/1962938974260904421

Do self-perpetuating B lymphocytes drive human autoimmune disease? Jonathan C W Edwards, Geraldine Cambridge, Vikki M Abrahams Published: 1999 [Line breaks added] Abstract Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are...

I know very little about the specifics of how all these drugs work. I think ideally you'd test with a drug that reduces neuron firing relatively globally in the nervous system since we wouldn't know what specific neurons or regions might be more important. A person would do an intense exercise...

The idea is basically something like every time a person does any kind of exertion, their nervous system receives a tiny dose of something akin to caffeine, amphetamine, or cocaine. [Edit: Like stimulants in terms of the effect, not necessarily an actual chemical being added to the brain.] The...

For reference, here is the main hand grip strength result: The light pink line is one hour after taking PS.

Yeah, no blinding.

Good points in your post. I have no idea how an infection would suddenly trigger such a disease, or how it could suddenly go back to normal. In terms of testing, I'd want to see more studies with larger sample sizes just testing if the above studies are noise or not. If they are actually...

Only thing I'd say is that from my quick search, the trend seemed to be that consistently (the above five studies), abstracts highlight findings in the activation direction and not people with ME/CFS having larger decreases in brain activity after exertion. Though I might have been biased in my...

I'm just learning the basics of neuroscience, so a lot of this is very foreign to me. But when I search for papers related to MRI, exercise, and ME/CFS, several highlight increased brain activation in one form or another after exertion that is absent in controls. The following are just from a...

Thread for the blood volume measurement system made by Daxor. "Daxor Corporation (NASDAQ: DXR) is tackling healthcare’s “multi-billion-dollar silent crisis”, the inability to precisely measure blood volume. This often results in suboptimal care, prolonged hospital stays, and increased...

Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation Swathi Jothi, Michael Insel, Guido Claessen, Saad Kubba, Erin J. Howden, Sergio Ruiz-Carmona, Todd Levine, Franz P. Rischard [Line breaks added] Abstract Post-acute...

New newsletter about BioQuest: "The Heart of the Matter - OMF has now received approval from the NIH to access plasma samples collected via the Chronic Fatigue Initiative, bringing the total number of samples for our large-scale ME/CFS biomarker project (BioQuest) to...

What if ME/CFS is an impaired ability to turn off excitatory neural circuits (or alternatively, inappropriate activation of these circuits)? I was watching an Intro to Neuroscience lecture, where the teacher described different kinds of micro neural circuits (at 24:30). There are positive...

I remembered that some people with irritable bowel syndrome avoid dairy. So I think the genetic correlation to not eating dairy is related to the genetic correlation to IBS and/or 43% of the DecodeME cohort having IBS. Prevalence and Presentation of Lactose Intolerance and Effects on Dairy...

Congratulations on the award Tom! Just seeing this thread for the first time. That's an incredible list of endorsements. Congratulations on that too. Thanks for all your work.

Online treatment regimens in chronic fatigue syndrome From the book, The Scientific Basis of Fatigue (Thread) Jaime Navarrete, Juan P. Sanabria-Mazo, Randy Neblett, Juan V. Luciano [Line breaks added] Abstract Some psychological therapy approaches have been empirically supported for the...

The risk may or may not be the same. But the benefit is exponentially higher. If a patient takes it themselves, it might help that one patient and maybe a couple more that are convinced by an anecdote. If a patient takes it as part of a trial, it could help millions of patients get that...

See thread: International Declaration in Support of Research and Drug Development for ME/CFS and Long COVID