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I actually do my best to avoid all psychosomatic threads. Today I have accidentally clicked through onto two of them and had a bit of a rant. You are right of course but I do feel a bit better now.

I am rapidly beginning to lose my patience with this messaging. Seeing the prophets of the false ideology that has deeply harmed me claiming that the information that would have saved my functioning is dangerous and causes harm is just too repulsive for words. The idea that it is knowing the...

This is so crazy. It's all so mad. Honestly madder than some of the antivax/wellness stuff. Like this is demonstrably more insane than, for example, people thinking that a drug or supplement that has no effecacy helps them. But cancer patients didn't use to be told out of fear they'd give up...

I am so sorry this happened to you. I can't imagine how hard that must have been. I know I bring it up a lot but I knew whatever was happening to me wasn't psychosomatic until my GP gaslighted me about it. He also basically refused to diagnose me, saying I 'didn't want' the label without...

I think I remember JE saying a while back there were already ideas on drug targets, and some potential ones may well appear when the dust has settled on DecodeME etc. But I may be misremembering. I have thought about this with regards to clinical trials. Because the risk of being worsened with...

This insane approach has dogged my entire adult life. Like has anyone stopped and thought how insane it is to claim that 40% of people seeking medical care are somatising? It's bonkers, it makes no sense. And telling people who are having extremely distressing symptoms that they are just normal...

Why is any study that acknowledges ME/CFS as a physiological illness using the Chalder Fatigue Questionare at all, let alone as a primary outcome?

Oh to be a fly on that wall 'While biological understanding of ME is still limited, planning for the future is essential. This includes preparing for the delivery of potential treatments, as identified by the ME Priority Setting Partnership.' So many questions that can't currently be answered...

If we think that ME/CFS after long covid is the same as ME/CFS after any other illness, then within a couple of years we will have pretty definitive answers on some JAK inhibitors with this, Wes Ely's bari trial and another one which I can't currently remember. I assume that different JAK...

Very well put. As someone who studied a lot about systems of control, capitalism etc etc, it was bizarre to find that I had still managed to be completely hoodwinked by said system, and then sort of be strapped into a front row seat to observe and be a victim of the emptiness and cruelty of the...

Oh this is very interesting, i didn't know about this. Edit: it says in the link that Finngen results are now 'publically available for the whole research community'. So it's entirely possible it's concurrent.

I reckon this is probably the Lipkin study that had funding pulled. Some of the US institutions seem to have won a court case to reinstate funding so maybe that will go ahead eventually.

Am I correct in thinking nature scientific reports is more prestigious than nature communications? Either way it's shocking this got published anywhere.

That occured to me but I didn't know if it was even possible to increase NK cells

A lot of the physical tics assoicated with schizophrenia are actually caused by the drugs commonly prescribed to treat it.

We are living in an age of utter delusion parading around as science. This is as nonsensical as any belief in wellness/antivax circles. And it sounds like it uses the PACE trick of telling the patients how effective it is, which tells us everything we need to know. I sometimes feel like the...

I guess I meant could it be a factor - this process going awry somehow. If ifn-g and cd8 t cells are the medium by which PEM is triggered during/after activity essentially. And in terms of long term deterioration I don't know. I suppose I was thinking of this process as adding fuel to the fire...

Could this possibly explain why pwME get PEM and sometimes deteriorate after exercise? I note IFN-G increase which is of course relevant to the Edwards/Cambridge/Cliff hypothesis.

JE has said a few times that there may be repurposeable mabs that will do the trick. I think it depends entirely on what drug targets come to light. For example yesterday: As for developing a new one, here is JEs best case scenario from a while back. I think the broad point is that if pharma...

'In how many years' is the pressing question about all this no one can answer it seems . Would it also block the monoclonals? Damn I didn't realise that.