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It could be worth pursuing then, even if tricky. Hard to get funding without more evidence though I'd imagine. Interesting, can you say more about this?

So a GWAS wouldn't pick it up if it was due to disordered expression rather than defect? A fascinating and horrifying thought. If there are no tests, is there any way to probe this hypothesis further. Hypothetically (ignoring the ethical concerns) could a drug be developed to target these genes...

All of these findings lately are making me think about the fact that I have had 'blood sugar crashes' since my late teens, the time when I developed several other issues that seem to have been almost a pre-ME or very mild-ME state. In these episodes I would get very woozy and dizzy and...

A nonentity of an answer that embodies the governments willfull ignorance over the realities of living with ME. The state supported me in my employment journey so well I went from fairly functional and mild to bedbound. Now this is all they can muster? Disgusting.

This is the team that is doing the nanoneedle replication attempt iirc.

'Simmaron has already found 130 age and gender-matched healthy controls over the past year, but they are not including a placebo arm in this trial because they’re seeking FDA approval for the drug in ME/CFS in another way. They aim to develop a diagnostic panel using pATG13 and BECLIN-1 to...

This stood out to me...

I stumbled across this earlier which looks interesting although it was serum and CSF. Also there was that muscle on a chip abstract and the two mice studies suggesting something in the blood causes ME like symptoms in healthy animals and tissues. Perhaps that is worth further investigating...

Whoever made the decision to print that last letter has blood on their hands. The Guardian editorial team cannot keep both sidesing this. People rightly or wrongly trust them to give them an accurate representation of science and this is the polar opposite.

I suspected I had 'Cfs' for years but the NHS page was terrible and didn't mention PEM, and doctors were dismissive. I assumed that it just meant I would be tired and ill forever unless it cleared up. I had no idea about delayed PEM or that I could get worse. The information about PEM and GET...

I agree about trying to replicate complement H and other complement findings, and hv3-30. I just want to say that I think severe patients should be studied as a priority. We have seen that severe patients may not have the hv3-30 finding and another recent paper found t cell dysregulation or...

I just want to chime in and say that the left and liberal academia in humanities really likes ideas of psychosomatic illness and the like. I wrote an essay on trauma in lit when I first had undiagnosed ME and the main secondary sources were all big on Freud and that. The Guardian also loves to...

By stopping the use of GET and curative CBT which is widely reported to lead to deterioration. Obviously this won't protect everybody but I and many others would likely still be mild If not for psychosomatic/bps interventions. And by teaching people and their carers how to manage their...

I am obviously not a scientist but I am extremely skeptical about the capability of a placebo response to induce a large improvement in an illness as disabling as ME. Many studies where a large placebo was reported are infusions with saline as placebo, and many people with OI report big...

Agree about uncertainty from a practical perspective. From a subjective perspective it's much more tricky. Since I became severe, I have lost count of the amount of times I have asked 'what is happening to me?'. I think we need to be clear on what exactly we are uncertain about to become...

So is this paper arguing for two entirely separate diseases? Or is this another situation with different stages or states being proposed as we discussed in the thread about the Ryback paper? My experience of mild ME for three and a half years before getting worse and hundreds of other stories...

Yes I can see that, although for a truly effective treatment that could significantly reduce or block PEM the tradeoff would likely be worth it. I suppose my concern is them finding drug targets that severe people don't have. Or there being additional complexities with the severe state and...

So the 'step' of severe ME might involve a shifting out of the step where the HV3-30 is increased and into a different process with a different starter? Like hypothetically if you go from moderate to severe then the disease process becomes different, but when you improve back to moderate you...

Different starter pathways is interesting. But how could severe ME have a different starter pathway if some people start off mild and stay that way for many years before becoming severe, and some lucky people who have been severe for many years recover to a moderate or mild level over time? And...

This is a fascinating finding and I hope it is the first step on a road to getting all of us some answers, but I do find the fact it wasn't replicated in severe ME worrying in a personal level. I'm sure i'm not the only person who is concerned that when the severe state is triggered something...