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I just read about ffmpeg integrating whisper to automatically subtitle videos and remembered this cropping up as a use case for a few people here. It’s available here https://ffmpeg.org/ Documentation here https://ayosec.github.io/ffmpeg-filters-docs/8.0/Filters/Audio/whisper.html If you’re...

Interesting given previous speculation about JAK/STAT inhibitors (the use of rituximab is also mentioned in one of the case descriptions). Here are the sections on measurements of cytokine responses, first the method And the results With details from Fig 4

Responding to an edited post. I may at times disagree with people on the best way to go around improving things for all or us but have always felt that’s happened in good faith in a friendly way and I recognise, value and appreciate others views greatly.

Great! Thanks. I think I’d checked every section except that one and was thinking a few of us could take a gene each and go off and do the leg work, but that makes things much easier.

It doesn’t look like there’s a good method of doing that in the Atlas, maybe just a google scholar search would get a start at coverage so something like this OLFM4 "genome wide" OR gwas or here’s a search for CA10 “genome wide” OR gwas? And I remember @forestglip was interested in this a while...

Wow! That’s a lot fancier than the squeezey bottle with a nozzle I have! I’d settle for the bidet shower attachment I used to have living in countries where those sort of things are the norm.

Lots of good questions. I’ve been thinking and I’m not sure. But I’d say things haven’t been moving forward in clinical care because there has not been an alternative. Patients, doctors, charities have and still do want to ‘do something’ and the only people offering ‘something’ have been the BPS...

I think I’ll stick wet wipes…

I agree with much of what you say @Sasha and I may have misunderstood parts of your proposal. You’re absolutely right that we need medics involved somehow. It’s perhaps easier in science because we have good examples now. The problem as we’ve discussed elsewhere is there are no good examples of...

Some more thoughts on the local MAGMA results above. The difference in the gene based analysis is worth looking at too. It would be useful to understand why (discussing with @forestglip we wondered if it was the difference in SNP conversion methods and assemblies used, or perhaps the reference...

I think the off ramp is as described, a path of least resistance for people based upon new evidence and solid science. Public displays of damascene conversions are unlikely and probably not helpful. Having prominent and respected people involved is part of the answer to me. As it looks as if is...

Yes looks that’s probably the case. The eligibility criteria seem to make that clear and I can see them being able to use the data in a publicly accessible tool like FUMA but not being able to share it. A shame as it limits our ability to remove variables that may be causing differences in...

All really good points, and having prominent people show a path for others to follow could be useful. Having some medical big guns on side could be really useful as you suggest. How it is done is important. Saying we need to improve care, look for treatments, invest in research to build upon...

I’ve been thinking more about this and it would be really useful if we could get hold of that UKB reference data to use with standalone MAGMA and see if it helps align our results. I wonder if it’s worth asking them? It’s not here https://cncr.nl/research/magma/ It’s mentioned here but not...

You’re right it’s something important to be aware of. And the suggestion @Sasha makes of having prominent figures open the door or show a path for others to follow may be useful or perhaps here are other ways they can help or influence things. I’m just far less convinced that there is a...

I hadn’t noticed but then again only just looked into who he was when you flagged it. Looks like a very handy person to have as part of the team! Really interesting, so it’s less a case of the rare variants completely changing the picture or being independent of the common variants found, but...

It's not though. The baseline assumption for the majority of people is that they don't know or even care about ME/CFS. The world we are living in is one in which ME/CFS has been ignored, it is that (and yes for some their positions) which has allowed a small group of people whose minds we will...

It looks from the paper as if the used a tool called coloc described in this paper: Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. Which I think does just compare individual gwas studies via their summary statistics. But one interesting...

There is one result from gene-set analysis I thought may be worth looking into On the group DecodeME_gwas1_infectious_onset the top result was this GSE2770_UNTREATED_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP (link to the MSigDB page for this set) This is a set which comprises "Genes...

Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes Riikka Lund, Tero Aittokallio, Olli Nevalainen, Riitta Lahesmaa Abstract Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and...