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  1. hotblack

    Open DSQ PEM survey - DePaul University, open October 2025

    “ The survey will take approximately 10–15 minutes” Well that’s wildly incorrect to start. There are 43 questions. How many of us can read, process, respond to 3-4 questions a minute. A healthy person maybe but… I wish more researchers got the basics right
  2. hotblack

    droracle.ai : What are the recommended treatments for chronic fatigue syndrome?

    Yeah, the problem here, as is so often the case, is it appears you have some grifters trying to make money. I suspect they won’t
  3. hotblack

    Review The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders, 2020, Missiroli et al

    This is part of special issue of the Journal of Clinical Medicine with the title “The Rise of Mitochondria in Medicine” which contains reviews like this but also research linking the mitochondria with innate immunity more widely as well as in specific diseases...
  4. hotblack

    Review Metabolism and Innate Immunity Meet at the Mitochondria, 2021, Bahat et al

    Metabolism and Innate Immunity Meet at the Mitochondria Bahat, A., MacVicar, T., & Langer, T Abstract Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...
  5. hotblack

    Review The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders, 2020, Missiroli et al

    The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C Abstract The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell...
  6. hotblack

    United Kingdom: Action for ME (AfME) news

    I can understand the negative feelings some have given all the history. I’ll be honest, my first reaction was more ‘wtf’ than anything. But others here raise some really good points. And I want to echo that it’s important we get senior and influential people from across all political wings on...
  7. hotblack

    droracle.ai : What are the recommended treatments for chronic fatigue syndrome?

    I’d never heard of this, it appears to be from a US based company called The Deep LLC https://finance.yahoo.com/news/thedeep-llc-artificial-intelligence-ai-184200084.html
  8. hotblack

    NHS England - E-learning Modules on ME/CFS

    Sounds like the David Strain created one released a month ago and already discussed in this thread? Interesting it’s being publicised by the NHS now though, I wonder if it’s been updated at all following feedback? The modified date for the session is now yesterday.
  9. hotblack

    Review The power and potential of mitochondria transfer, 2023, Borcherding et al

    In my head it was more localised interferon only, with the EV or free mitochondria being the routes for this to travel between separate sites. Precisely because we don’t have or see systemic interferon levels raised. One of the biggest flaws is probably… if these exported and damaged/interferon...
  10. hotblack

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    It wasn’t the direct contact route I was most interested in but the other two routes mentioned in the paper, release and capture through EVs or even free mitochondria. As I think I mentioned in another thread I’m very much in throwing stuff at the wall and seeing what sticks territory, with...
  11. hotblack

    How do you use AI for medical feedback?

    For the sort of usage described here no and I absolutely wouldn’t. It’s understandable to want to try everything and anything but I’d really caution against this sort of use. We’ve seen how LLM chatbots can lead people, particularly those who are vulnerable or desperate, down iffy paths. It’s a...
  12. hotblack

    New podcast on medical innovation - Hard Drugs

    There’s been a couple more episodes of this which are well worth a listen 100 years of insulin in 15 minutes is really interesting and short Hacking proteins with AI is longer but with other threads talking about AI seems particularly relevant. Along with an article from last year How Neil...
  13. hotblack

    Will AI programs/models significantly aid in producing viable treatments for ME/CFS?

    I found this difficult to answer because of the significantly qualifier and different people’s understanding… But in short, they already are, just not in the way public discussion often goes. DecodeMe used AI/ML. Other papers on here use AI/ML and AI/ML is being used in labs for things like...
  14. hotblack

    Preprint Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts, 2025, Sardell+

    It looks like the Results has been changed too with this detail added And they’ve changed some gene findings and categorisation too, from this To this With this they’ve gone from 77 novel gene associations found to 75.
  15. hotblack

    Preprint Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts, 2025, Sardell+

    What’s changed, they say From a visual inspection it looks as if the Discussion section is where the main changes are. There’s a new subsection “First Genetic Evidence in Endometriosis for Many Genes “ and an extra paragraph n “Novel Drug Discovery and Repurposing Targets” Although there...
  16. hotblack

    Deep Sequencing of BCR Heavy Chain Repertoires in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Ryback et al

    I remember that 2019/20 winter before covid they were collecting but obviously stopped, as I had been scheduled to give more blood. I’m not sure exactly when they restarted but Caroline was doing limited home visits later in 2021 IIRC. The Ryback paper mentions it uses the same samples as...
  17. hotblack

    How would an Average pwME/carer (no biology knowledge or access to S4ME) be able to tell when a mechanism has been discovered vs bio “memes” and hype?

    Probably not if it doesn’t directly impact them. It’s just vaguely interesting stuff that washes over you. Most of us are probably only pretty superficially interested in things until it means something to us tbf.
  18. hotblack

    Updates from the UK ME/CFS Biobank / CureME team

    I can’t see this on the CureME website or social media but ME Research have posted that those set to receive the free samples from the Biobank have been announced. Hopefully we’lo get more details soon.
  19. hotblack

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Thanks for the update, it all sounds very interesting. I’m sure we’re all joining you in crossing things regarding funding. Maybe Twoflower will turn up with some gold!
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