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I'm just learning the basics of neuroscience, so a lot of this is very foreign to me. But when I search for papers related to MRI, exercise, and ME/CFS, several highlight increased brain activation in one form or another after exertion that is absent in controls. The following are just from a...

Thread for the blood volume measurement system made by Daxor. "Daxor Corporation (NASDAQ: DXR) is tackling healthcare’s “multi-billion-dollar silent crisis”, the inability to precisely measure blood volume. This often results in suboptimal care, prolonged hospital stays, and increased...

Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation Swathi Jothi, Michael Insel, Guido Claessen, Saad Kubba, Erin J. Howden, Sergio Ruiz-Carmona, Todd Levine, Franz P. Rischard [Line breaks added] Abstract Post-acute...

New newsletter about BioQuest: "The Heart of the Matter - OMF has now received approval from the NIH to access plasma samples collected via the Chronic Fatigue Initiative, bringing the total number of samples for our large-scale ME/CFS biomarker project (BioQuest) to...

What if ME/CFS is an impaired ability to turn off excitatory neural circuits (or alternatively, inappropriate activation of these circuits)? I was watching an Intro to Neuroscience lecture, where the teacher described different kinds of micro neural circuits (at 24:30). There are positive...

I remembered that some people with irritable bowel syndrome avoid dairy. So I think the genetic correlation to not eating dairy is related to the genetic correlation to IBS and/or 43% of the DecodeME cohort having IBS. Prevalence and Presentation of Lactose Intolerance and Effects on Dairy...

Congratulations on the award Tom! Just seeing this thread for the first time. That's an incredible list of endorsements. Congratulations on that too. Thanks for all your work.

Online treatment regimens in chronic fatigue syndrome From the book, The Scientific Basis of Fatigue (Thread) Jaime Navarrete, Juan P. Sanabria-Mazo, Randy Neblett, Juan V. Luciano [Line breaks added] Abstract Some psychological therapy approaches have been empirically supported for the...

The risk may or may not be the same. But the benefit is exponentially higher. If a patient takes it themselves, it might help that one patient and maybe a couple more that are convinced by an anecdote. If a patient takes it as part of a trial, it could help millions of patients get that...

See thread: International Declaration in Support of Research and Drug Development for ME/CFS and Long COVID

This was presented at the International ME/CFS Conference 2025 a few months ago: Link "Prof Christian Puta provided a poster presentation on behalf of Prof Philipp Reuken on differentiating ME/CFS through Raman spectroscopic profiling of immune cells. In their study, Raman spectroscopy was...

Differentiating ME/CFS Through Raman Spectroscopic Profiling of Immune Cells Anuradha Ramoji, Frida Naumann, Tze Ching Yeo, Sabine Vonderlind, Aikaterini Pistiki, Hulya Yilmaz, Iwan W. Schie, Oleg Ryabchkov, Thomas Bocklitz, Andreas Stallmach, Jürgen Popp, Philipp Reuken [Line breaks added]...

I'm happy to see that they'll be measuring IGHV3-30 during this study. We'll see if there's more confirmation that it's high, and maybe see how it relates to improvement, if there is any.

Bluesky thread from the author going over the results. A couple interesting points:

Thanks. It looks like the protocol, not results, though.

See the following relevant thread: Sweden: Have the ME and CFS clinic in Gothenburg found a loophole to avoid the diagnosis ME?

From the first citation: Quite a stark difference. Some discussion here: https://www.s4me.info/threads/coq10-coenzyme-q10.13640/post-259964

Up to now, I've mostly tried to avoid reading or posting research that involves animals, because I find the practice often is abhorrent, and I don't want to support more of it happening. Making mice fear for their life in a swimming test, injecting animals with chemicals that we would never...

Exploratory Study on Autoantibodies to Arginine-rich Human Peptides Mimicking Epstein-Barr Virus in Women with Post-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Friederike Hoheisel, Kathrin Maria Fleischer, Kerstin Rubarth, Nuno Sepúlveda, Sandra Maria Bauer, Frank Konietschke...

Crosslinking this announcement from the ME Association thread: https://meassociation.org.uk/2025/08/the-me-association-awards-decode-me-the-howes-goudsmit-award-2025/