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Summary of the quality control checks they recommend that GWAS studies perform: And here are the summarized results of their quality control analysis of the 6 GWAS or TGAS that had been done at the time: Only Herrera et al performed all these recommended quality control checks. They give...

Am I misunderstanding what "Cor. #Treatments" and "Cor. Symptoms" represent? How can a correlation of .00001 give you a p-value of .01776? All the "most perturbed plasma proteins" have tiny correlations with number of treatments or symptoms, yet significant p-values with only 31 participants...

I agree. I feel like with expression, metabolite, brain imaging findings etc, ~90% of the findings might easily end up being products of lifestyle: low physical activity, diet, medication, etc. We've got a handful of the really good stuff, the genetic causal studies, with another really big one...

Things I want to keep an eye on, after reading and discussing the paper with an AI to better understand. (AI quotes slightly edited for clarity and links to GeneCards added): CSMD3 and PTPRD had many significant variants, and included some of the lowest p-values and largest effect sizes of the...

Vitamin D blood levels and vitamin D receptor polymorphisms contribute to post-acute sequelae of severe acute respiratory syndrome coronavirus 2 severity in the pediatric patients Pei-Chi Chen, Yu-Lung Hsu, Yen-Hsi Chen, Chih-Yu Lin, Miao-Hsi Hsieh, Hui-Ju Tsai, Wen-Shuo Kuo, Hui-Fang Kao...

Commentary: Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis Runhua Zhang, Hongxia Hu We read with great interest the recent systematic review and meta-analysis evaluating the efficacy and safety of XYS for the treatment of...

Open Medicine Foundation: 'Steroid Dynamics in ME/CFS: New Publication' The Heart of the Matter OMF’s research centers in Uppsala and Melbourne published a study of steroid hormones—molecules that control a lot of important systems in the body—using an advanced technique called...

Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry Natalie Thomas, S. J. Kumari A. Ubhayasekera, Christopher W. Armstrong, Katherine Huang, Jonas Bergquist [Line...

I see that a new version was submitted on July 11 and posted on July 15. They did a big overhaul of the references. I checked a handful and they seem to be real papers now. Nothing about the text is changed except they updated/added citation numbers and removed the bit that said they used AI...

That result doesn't feel very strong. Higher CD8 in only one of five six symptom-based subgroups, and not even in both sexes. Edit:

CXCR5 on Wikipedia:

Aberrant T-cell phenotypes in a cohort of patients with post-treatment Lyme disease Alexander A. Girgis, Raffaello Cimbro, Ting Yang, Alison W. Rebman, Thelio Sewell, Daniela Villegas de Flores, Aarti Vadalia, William H. Robinson,, Andrea L. Cox, Erika Darrah, Mark J. Soloski, John Aucott...

SARS-CoV-2 Semi-Quantitative Total Antibody Correlates with Symptoms of Long COVID in Both Vaccinated and Unvaccinated Subjects James R White, Ralph L Abraham, Wyche Coleman,Eddie Pitre, Megan M Stevenson, Hannah L Kaplan, Alexander G Goldberg, Molly A. Allen, Cecilia A. Castro, Abby A. Haddox...

Similar authors and scope to this other recent paper: Cost effectiveness of non-pharmacological interventions for fatigue in patients with long-term conditions: a systematic literature review, 2025 Davis+

Effectiveness of non-pharmacological Interventions For Fatigue in Long term conditions (EIFFEL) - systematic review and network meta-analysis Joanna Leaviss, Christopher Burton, EIFFEL study group, University of Sheffield [Line breaks added] Objective To assess the clinical effectiveness of...

Yes, my main fear that prompted the post was the ambiguity of, for example, an HLA allele finding. It might just cause people to get sick more severely and more often, which doesn't really seem that interesting in terms of how to treat ME/CFS if the subsequent disease process has nothing to do...

Very good points. It might be more trouble than it's worth if it only controls for a tiny portion of the phenomenon.

Good question, I'm not sure how correction would work in that case.