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Link to publication here ****************************** Beneficial effects of intermittent intravenous saline infusion in dysautonomic patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a caseseries Per Sjogren, Helena Huhmar, Bo Christer Bertilson, Björn A Bragée, Olli Polo...

I agree. From the trailer, it looks like a talented film-maker as well. This quote hit me like a train: Edit: fixed typo

What Doesn't Kill You Lives in the grip of ME/CFS ✓ Coming in 2025 ✓ 100% of profit reinvested in ME/CFS research and education "What Doesn't Kill You" is a forthcoming documentary exploring the lives of people battling ME/CFS, a scandalously underfunded and chronically ignored disease...

While IgG4 did go down more in responders, that's probably because it was four times higher at baseline in responders than non-responders. So maybe high baseline IgG4, like high NK cells, might be an indicator of who will respond. Table 2:

I read this and it was really helpful. I started Janeway's after, and that first book made it much easier and less intimidating to digest Janeway's. Though I paused Janeway's after they started talking about biochemistry concepts I had no clue about, so now I'm taking a detour on more basic bio...

Multifaceted evolution focused on maximal exploitation of domain knowledge for the consensus inference of Gene Regulatory Networks Adrián Segura-Ortiz, Karen Giménez-Orenga, José García-Nieto, Elisa Oltra, José F. Aldana-Montes [Line breaks added] Highlights • BIO-INSIGHT optimizes GRN...

Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson’s disease Hussein Kadhem Al-Hakeim, Hayder Naji Khudhair, Sayed-Omid Ranaei-Siadat, Fataneh Fatemi, Fateme Mirzajani , Mengqi Niu & Michael Maes [Line breaks added] Abstract Parkinson’s...

I put the results section from the preprint and the final paper in a diff checker (left hand side is preprint): https://www.diffchecker.com/lt6Xaxmg/ They didn't add anything there that makes it clearer that the chart is basically meaningless.

Probably, but I can only definitely say that's the case (really bad PEM plus sore throat and runny nose) for the time it happened a few days ago. I didn't think to track it in detail previously.

Yes, four patients were added later:

Only when I really overdid it, but yes, sore throat and runny nose.

Thread for discussion of paper: Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

Alain Moreau responded to an email: Corrected legend: Edit: Note that I think he meant Supplementary Table S3. It has most of the items from the original legend, but not all, though.

I just sent an email letting him know.

Health Rising: 'The Best of Times, The Worst of Times: Ian Lipkin Talks on ME/CFS' Includes an interview with Ian Lipkin:

It seems like some charts are missing from figure 2. The caption talks about fig 2a through 2n, but I only see 2a through 2g. And 2b through 2g in the image seem to correspond to 2i through 2n in the caption, with 2b through 2h missing.

Interesting that they never refer to it as ME/CFS. Only ME, with a note that it's also known as CFS.

It's the MET rate metric:

This might be the thread you're thinking of. Also, this website discusses the difference. Basically, GWAS looks only at the most common variants, so it could miss a lot. WGS looks at the whole genome, and also looks at different types of mutations that a GWAS doesn't.