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I made a thread here: Genetics of PANS/PANDAS, 2025, Lachman et al

Genetics of PANS/PANDAS Herbert M. Lachman, Jennifer Frankovich, Peter J. van der Spek, Janet L. Cunningham [Line breaks added] Introduction Pediatric Acute-Onset Neuropsychiatry Syndrome (PANS) is an enigmatic condition characterized by the abrupt onset of obsessive-compulsive disorder (OCD)...

@Jaybee00 let me know about this: ---- - https://xcancel.com/mildTin/status/1936644648078074275 Discussion of trial starts at 36:25

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Drug: Ibudilast 10mg pills, 2 pills twice per day Other Names: Drug: Pentoxifylline 400mg pill 3 times per day Other: Placebo Placebo matching ibudilast, 2 pills twice per day OR placebo matching...

I searched for any results on S4ME for the genes associated with SNPs above. Here are the ones with matches: PDE4B Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+ Evidence of shared genetic factors...

Just copying their findings from the supplementary tables so the genes come up in forum searches. For the snps, I converted them to the genes they map to with dbSNP's API. Variants Transcription Proteins

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study Eleni Friligkou, Solveig Løkhammer, Brenda Cabrera-Mendoza, Jie Shen, Jun He, Giovanni Deiana, Mihaela Diana Zanoaga, Zeynep Asgel, Abigail Pilcher, Luciana Di Lascio...

Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relation between physical frailty and neuropsychiatric disorders Pei-Yang Gao, Yan Fu, Xiao-Yu He, Dan-Dan Zhang, Hao-Chen Chi, Yi-Ming Huang, Zhi-Bo Wang, Wei Zhang, Ya-Nan Ou, Yi-Jun Ge, Jia You, Ling-Zhi Ma, Yi-Xuan...

Military Exposures and Early Menopause: Findings From the Gulf War Era Cohort Study (GWECS) Carolyn J. Gibson, Guichan Cao, Sabra Inslicht, Allison D. Altman, Caitlin E. Haas, Aaron Schneiderman, Erin Dursa [Line breaks added] Objective Traumatic and environmental exposures during military...

The link formatting got messed up. Here's a working link: In which way could Psychiatry and Psychology help investigate ME/CFS (and what exactly is Neuropsychiatry?)–Discussion Thread

S4ME thread: Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder, 2025, Wdowiak et al News article linked in above thread: Timeline and symptoms somewhat comparable to PEM.

PsyPost: 'Rare post-orgasm illness causes days-long flu-like symptoms, but research into its cause remains limited' 'A rare and poorly understood condition known as post-orgasmic illness syndrome, or POIS, causes a wide range of flu-like and allergic symptoms following ejaculation. These...

Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder Krystian Wdowiak, Agnieszka Maciocha & Julia Wąż [Line breaks added] Abstract Post-orgasmic illness syndrome (POIS) is a rare condition characterised by flu-like and allergic symptoms that...

I pulled all the significant findings, in either males, females, or combined, from the BMI-corrected findings. I did a very quick and dirty search to see which direction they are expected to change with increased BMI. I bolded the ones that were the opposite direction or were a bit more...

Ah, he's pretty much explicitly saying that depression is "all in your head". And his point is that 'omics studies of "all in your head"-diseases find markers in the blood, so the present study's results don't show ME/CFS isn't all in your head.

From the abstract of the Nature paper: There seems to be little to no overlap between significant results in the two papers. By similar results, does he mean they both did 'omics studies?

The Carson comment is just blatantly wrong, so I sent an email to SMC to ask they correct it:

I see. Still, maybe it would have made sense to just try to match the distributions of BMI exactly by excluding as many controls as necessary. There were so many controls that I'm not sure that would have been much of an issue in terms of statistical power. Maybe we should be looking for...

The above mostly seem like markers I'd expect to be associated with high BMI. There was only slightly higher BMI in cases (~1 point for males and ~2 points for females), but with sample sizes this large, could that be enough to make BMI markers significant? They seem to have done some kind of...