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    UK BACME ME/CFS Guide to Therapy 2025

    especially as their model has no room for a scenario in which their involvement isn't needed. Patient recovers, or doesn't recover but grows more confident in managing despite the illness - tick in the box for therapeutic help. Patient shows no improvement or gets worse - more therapeutic help...
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    UK BACME ME/CFS Guide to Therapy 2025

    With the scattering of extra capital letters it reads like a random Facebook comment rather than something put out by a professional organisation.
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    [Abstract] Impact of [LC] on Physical Activity and Sleep: a Matched Cohort Study using Wearable and EHR data From [All of Us], 2025, Chen et al

    One thing possibly worth mentioning is the step count graph, which shows that most people's daily steps change very little around the time of acute Covid infection (a few plummet right down briefly, maybe because they forgot to put the Fitbit on that day, but even those bounce back up again)...
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    [Abstract] Impact of [LC] on Physical Activity and Sleep: a Matched Cohort Study using Wearable and EHR data From [All of Us], 2025, Chen et al

    So, if you use '200 clinical predictors' to classify people into 'probably healthier' and 'probably less healthy', you find that the second group take fewer steps on average and don't sleep so well.
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    United Kingdom News (including UK wide, England, NI and Wales - see separate thread for news from Scotland)

    or caught it from their children, who are impervious to it according to most of the medical establishment.
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    Evaluation of Interventions for Cognitive Symptoms in Long COVID, 2025, Knopman et al

    Or they'll cite it as proof that all three kinds of rehab are equally effective. Like they keep on citing REGAIN as proof that physical therapy and "behavioural support" are effective.
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    Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID... , 2025, O'Connor et al.

    One easy way to reduce your stress level is to avoid assessing the severity of 8 of your symptoms every 3 hours for 24 days.
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    Evaluation of Interventions for Cognitive Symptoms in Long COVID, 2025, Knopman et al

    Unfortunately the 'Summary of Clinical Trial Results' has been written so as to suggest all three rehab approaches were effective. https://recovercovid.org/sites/default/files/summaries/RECOVERClinicalTrialNEURO.pdf Nowhere in the document does it state the fact that they found no evidence of...
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    Evaluation of Interventions for Cognitive Symptoms in Long COVID, 2025, Knopman et al

    The bar is set so low that I'm genuinely impressed with them for stating the lack of benefit, rather than digging out some vaguely positive speck of data and writing it up as their main finding. Also they seem to have more authors than participants. Generally that might be a red flag for a...
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    How do we stop charities and influencers spreading bio-babble about ME/CFS?'

    Vaccination would be another example. There is astonishing misinformation going around about vaccines, people promulgating the weirdest ideas, but this hasn't led to medics deciding to give up vaccinating anyone - because they are confident that what they have to offer is better than what the...
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    How do we stop charities and influencers spreading bio-babble about ME/CFS?'

    But if S4ME is going to advise families to stick to saying 'my child can't do XYZ because it makes them ill', rather than 'my child can't do XYZ because it makes them ill due to [unproven theory]' because the second form of words will expose them to safeguarding procedures and allegations of...
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    MRC/NIHR DecodeME Showcase meeting online and in person Nov 6th

    It just seems we are in bizarro-world when the MRC co-hosts a showcase intended in part to "Highlight the bespoke support available from NIHR and MRC for researchers in preparing applications", including representation from an organisation which can't apply to the MRC to get funding for its...
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    MRC/NIHR DecodeME Showcase meeting online and in person Nov 6th

    re MRC saying they are ready and waiting to fund what they consider to be good research proposals: Does that mean SequenceME has been turned down for funding by MRC, or never applied?
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    How do we stop charities and influencers spreading bio-babble about ME/CFS?'

    I've just happened to look at the ME Association's article 'LONG COVID AND ME/CFS: Are they the same condition?' https://meassociation.org.uk/wp-content/uploads/2025/10/COVID-19-LONG-COVID-MECFS-ARE-THEY-SAME-CONDITION-V1-1.pdf it's full of stuff about mitochondrial dysfunction, dysregulation...
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    Trial Report [Abstract] - Individualised aerobic and resistance exercise training improves exercise tolerance in individuals with [LC]: [PERCEIVE], 2025, Howden+

    Oh I get it. Thanks. Still think the range of 2-225 for the aerobics sessions (in 180-odd days) is a bit startling.
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    Trial Report [Abstract] - Individualised aerobic and resistance exercise training improves exercise tolerance in individuals with [LC]: [PERCEIVE], 2025, Howden+

    "median of 68 resistance (range 1-68 sessions)" can't be right, can it? Anyhow, it's clear from that sentence that adherence was extremely variable - some participants doing almost no exercise and others doing more than 1 session per day for 6 months - and yet the results are phrased as if the...
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    Independent: Father attempted suicide and family almost lost home after GP missed common genetic condition for six years

    Going by the experience of a friend who has had a delayed diagnosis of haemochromatosis - as a woman of childbearing age, you get fobbed off with "of course you're tired, everyone's tired these days [eyeroll]", "have you tried yoga" and "do you want antidepressants?"
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    Preprint Virus Genome Sequences in the Blood of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients, 2025, Davis et al

    So none of the healthy controls has signs of a really common human herpes virus, but nearly half of them have a bat virus? Were they recruited from a superhero lair under Gotham City?
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    What Can We Learn Four Years On? A Multi-Centre Service Evaluation Exploring Symptoms, Functional Impact, Recovery and Care Pathways…, 2025, Lee+

    Noteworthy that on their radar chart of symptoms the 'slight', 'moderate' and 'severe functional limitations' groups all make more or less the same shape, while the 'negligible' one has a very different shape (fatigue plus lung/cardio problems but not much else). It would be interesting to see...
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