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Great work, thanks to all authors!

The intervention also consists of only 2 sessions. I wonder if people who truly believe in mind-body recovery programs are frustrated by papers like this or is it really anything goes...

There are millions of people in chronic pain while shootings like the one by Mangione almost never happen. So I don't think there is a strong connection here.

The effect sizes they report in the abstract (around half a standard deviation for fatigue) are inflated by including the Qiqong trials. For short-term fatigue, for example, the PACE trial found an effect closer to 0.2 instead of 0.5 SD. The same for other outcomes.

They included 4 Chinese trials of Qigong exercise and 1 of isometric yoga. Also included are the GETSET trial (Clark 2017), the PACE trial (White 2011), a very small (n = 14) Australian trial comparing two types of exercise (Sandler 2011), and the Spanish trial by Nunez et al that combined GET...

Just read the full text and it is great to see the methodological quality of the study. They used blinding, randomization, pre-registration of the analysis plan. They graphs are clear, the statistical models are reported explicitly, there's a good overview of potential limitations. No long...

Sad that that this paper couldn't find the same result of 'something in the blood' but good that they checked anyway.

Don't think so after a quick look, but hope to have a closer look towards the end of the year.

This publication is only on male ME/CFS patients. An earlier paper contained the data on female ME/CFS patients: Giloteaux L, Glass KA, Germain A, Franconi CJ, Zhang S, Hanson MR. Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome...

I try to follow ME/CFS research as closely as I can and sometimes write blogs about them. For example, at the end of the year I write an overview of the most interesting studies of the year, which helps to keep track of the most important ones...

Only read the abstract but sounds like an impressie difference.

They included '6 studies', 4 of which are papers from the PACE trial (I wonder if they fully realise this is the same study/trial?), one is the GETSET study and one is the review of patient surveys by Keith Geraghty.

You posted about age of onset. I was wondering if you have data on actual age at the time of the survey and if the cohort from the Netherlands was younger than that of other countries?

I wonder if increased leptin and fatty acid-binding proteins (FABPs) are simply due to ME/CFS patients having relatively more fat. Patients and controls have a similar BMI but the composition of their body mass might be different: more fat and less muscle for ME/CFS patients?

Thanks for checking! I hope will see more studies like this that test large amounts of data and make it all available online. It offers so much more possibilities for us (and other researchers) to check particular results and compare them to other studies. Making data available online is a...

There is the group of Sanne Nijhof and Elise van de Putte who developed FITNET, an online and quite assertive form of CBT. It aims at full recovery, includes graded activity and is similar to the CBT version of Bleijenberg and Knoop. Their team works at the WKZ in Utrecht which is probably the...

Could you explain this a bit more? I think it might be hard to tell if improvements are due to exercising or the improvement that made exercising possible in the first place.

Complement C3 has come up in a couple of studies before, for example this one: Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping - PubMed

Also see no good solution. I kept them in, hence why there are two datapoints for, leptin or for 'Fatty acid-binding protein, adipocyte'. For example, if there are two rows for leptin in the Hoel dataset and 1 in the Germain dataset, it would duplicate the latter and have 2 rows for leptin in...

The fold changes are not symmetric around 1. It's a ratio of the abundance of the ME/CFS group versus controls. So if the ME/CFS group had higher values, the ratio could be somewhere between 1 and infinity. If the ME/CFS group had lower values it would be somewhere between 0 and 1. That...