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Forensic biomarker discovery: Utilising metabolomics to elucidate prospective fatigue biomarkers for eventual roadside detection Aaron Hamilton, Luke Whiley, Maria Kadyrov, Brendan Chapman Highlights • Metabolomics can be used to identify biomarkers for fatigue. • Scyllo-inositol...

Agree with other posters - very well written and thorough. I wonder if the diagnostic criteria might be a factor. CCC in Fluge et al, but CCC and/or IOM here, so maybe the factor in the blood wasn't necessarily related to ME/CFS, but was related to a comorbidity required by CCC but not by IOM.

Here's an association, but this specifically is only describing healthy controls. It's a positive correlation between Vitality (SF-36) and IGHV3-23/IGHV3-30. r=0.527, q=0.039. The more they have the healthier they are, so opposite direction of the association between controls and ME/CFS in the...

Wow I just put together that chillier is the one of the people from your 'something in the blood' post. The username makes sense now, I thought they were just cold. Someone asked if she falsified the nanoneedle study. She said it's hard to compare her result to Ron Davis's, but that Fatima...

The study status is now "Withdrawn - Company focus shifted".

Nature: "Science-integrity project will root out bad medical papers ‘and tell everyone’" ---- 'The Center for Scientific Integrity — the non-profit organization that runs Retraction Watch — has launched a project aimed at rounding up flawed and fake medical-research papers and neutralizing...

Now published: Link | PDF

Pathogen-specific exposure is associated with multisite chronic pain: A prospective cohort study Jialiu Fang, Zemene Demelash Kifle, Jing Tian, Silvana Bettiol, Flavia Cicuttini, Graeme Jones, Feng Pan [Line breaks added] Abstract Evidence suggests that pathogens may influence pain perception...

Deoxygenation Trends and Their Multivariate Association with Self-Reported Fatigue in Post-COVID Syndrome Anja-Maria Ladek, Marianna Lucio, Andreas Weiß, Thomas Knauer, Helena Sarmiento, Miriam Ilgner, Marie Jakobi, Laura Barteczko, Marion Ganslmayer, Jürgen Rech, Antonio Bergua, Christian Y...

Quote from another thread, but thought it'd be good to post this response here. I put the top 115 genes into STRING to see the connections between proteins. HLA-C only has evidence linking it to one other protein with medium confidence, PSMB5. The same graph in interactive form can be seen...

The search engine AIs are very bad with hallucinations, much worse than the stand-alone chatbots. I wouldn't ever trust the Google Search AI without checking its sources. I mean that's good practice with any AI, but I feel like with the search AIs it's basically a coin flip whether it just makes...

That's kind of surprising. Are you sure you don't have any kind of custom instructions referring to ME/CFS that could influence it to answer in this way?

This looks very similar to another recent study that was on PVFS: Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study, 2025, Wang et al They both used the same 731 immune traits from a separate GWAS, although this thread's study also looked...

I don't know what this abstract is from. It came up on Google Scholar, but I can't find a mention of it anywhere else.

Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients Henrique Chapola, Katarina Lien,, Sissel Dyrstad, Per Ole Iversen, Karl Johan Tronstad [Line breaks added] ME/CFS is characterized by post-exertional malaise (PEM) and delayed...

Thank you for the color coding. What a good idea for quickly seeing matches. Adds some colorful decoration to the thread as well.

The proteins enriched in the neutrophil pathway at baseline were PSMA5, RAP1A, KPNB1, TXNDC5, RAB7A and at 15 minutes post-exercise were ERP44, RAP1A, GSTP1, DSG1, TXNDC5. All lower in ME/CFS EVs. Neutrophils were a hot topic in the study from a few days ago: Preprint Charting the Circulating...

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...

Bio-IT World: 'A Practical Precision Medicine Approach to Complex Chronic Diseases' ---- 'Based on unpublished data, the “strong expectation” of investigators is that all nine of the genes thought to be common to ME/CFS and long COVID will be a reproducible finding. The All of Us dataset used...

Ah yeah, YouTube guessed meltsey and Claude guessed that meltsey meant ME/CFS from context. I tried another method of getting the auto-generated Norwegian subtitles and asking Claude to do the translation as well. I was adamant that it should not change content and to put anything it wasn't sure...