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I have recently had thoughts organising in my head so wrote them down to help. This is maybe a continuation of discussions or ideas in A Thought Experiment on Muscles and possibly outright theft of other people’s ideas but maybe I can pretend I’m standing on the shoulders of giants or it helps...

Going over this again with a little more understanding (dangerous) and context of other studies and recent discussion. Is it fair to say there are some questions over some of the conclusions/interpretations here but the general picture of perhaps subtle shifts in the makeup or profile of immune...

I had some issues adjusting and had to tweak things until it felt right, I’m wary of giving advice for obvious reasons. There is a longish half life for ivabradine and any medication changes can take some time. But am glad to hear you have a cardiologist giving advice.

That’s the position I’ve moved to. Dying gasps of an old order under threat or even as it moves into irrelevance. Not to be panglossian, the path to change will be long and we’ll no doubt face obstacles. But it seems we’re moving to a point where we’ll have the tools to overcome them and the...

Exactly this. The political context and timing should not be underestimated.

What a tease! It seems there are at least useful results from DecodeME then, which there was never a guarantee of. That in itself feels like positive news. If the data can help to start to tie together things together in a bigger picture even better.

Development of myalgic encephalomyelitis/ chronic fatigue syndrome: A neurobiological construct Trond Myhrer Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling medical illness with unknown etiology and consequently without causal therapy. In the present study...

Great, thanks for the context @Jonathan Edwards that’s very useful. Most fields have their bibles, I hope this can become that for this field. Perhaps with an addition or two over the coming years!

Forgive me for my ignorance, can someone explain the significance of this? It looks to be a book describing methods of (largely already published) papers, is that correct? In which case what does this add? Is it more detail on those methods and how to reproduce them than is provided in the papers?

Interesting that there’s a new paper on this. I look forward to finding out what it says and if they replicated previous findings. Does anyone have access? Thread on the previous paper on this topic by this group Developing a blood cell-based diagnostic test for ME/CFS using peripheral blood...

Has anyone heard any news out of the APPG meeting yesterday? Will be interesting to hear how it went and more detail on the discussions and presentations

Yes, there was some mention of this in papers I was looking at recently around a related area discussed on these forums. And it’s difficult because neuroplasticity is a thing, but gets distorted or used inappropriately into another thing by some people. Probably a wise way of looking at it. I’m...

It is, very! I was thinking along the lines of what people like Paul Cisek have argued, if you’re familiar with his work. If not I’ll dig out some presentation of his for you. All very interesting stuff. And yes, agree with your other points. I think there’s a few reasons for the push towards...

Thanks for the additional detail @Kiristar it and the rest of your work on this are very much appreciated

All good points. I suppose I was thinking more widely than LLMs. I’m not sure if a transformer architecture itself precludes usefulness. Having an attention mechanism introduce a more relational aspect and allowing information from the input at inference time to be included could be useful...

Hope so. Interesting in the context of age of samples and costs of keeping them which was brought up recently IIRC. Hopefully it’s just the former and they want people to use them while useful rather than issues over the latter

I’ve caught up now and agree with a lot of what @jnmaciuch has said, so don’t want my post to be seen as a response to that. Perhaps all I’d add is that where I see some value is not in any AI tool giving us an answer but in being partners, tools for researchers. But instead they often seem to...

Sorry if this misses some recent posts, something I wrote before catching up with the thread.. Maybe I can provide another perspective or perhaps some new data to this conversation. I wonder, can we express new ideas if all we are using is the same words? ML/AI is often just showing patterns...

Well this looks all rather unpleasant. The mention of Leeds reminds me of when a local service seemed to be, very kindly, trying to arrange for me to be ambulanced up there. Given the impact of much shorter journeys in ambulances and a trip to a local hospital I said no. A decision I’m rather...

That’s probably why it appealed to me :) I think we’re all looking forward to your, Jo and Jackie’s paper, the DecodeME results and the influx of neurobiologists! Until then we can amuse ourselves learning things and prodding and pulling at other things.