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Basic process seems to be fairly common ML.. - Get a good dataset, filter out similarities from other reasons like being related - Train a network on this dataset, the idea being you know the inputs and output and are searching for what commonalities may exist in the data - Once trained use his...

More info on their previous HEAL model in this paper https://pubmed.ncbi.nlm.nih.gov/30193110/ And on the STRING database used for protein protein interaction networks https://pubmed.ncbi.nlm.nih.gov/36370105/ I’d definitely be interested in those who understand this properly giving some...

Mixed methods study of views and experience of non-hospitalised individuals with long COVID of using pacing interventions Christel McMullan, Shamil Haroon, Grace Turner, Olalekan Lee Aiyegbusi, Sarah E Hughes, Sarah Flanagan, Anuradhaa Subramanian, Krishnarajah Nirantharakumar, Elin Haf...

This popped up in my google scholar alerts too, due to the mention of ME/CFS, which from their definition I’m not convinced the author understands particularly well. I don’t think they're trying to dismiss it, just don’t understand it. There’s acknowledgment of people not being believed etc...

It does sound great, both what they’re doing here and what you describe Kitty. Adding an air to air heat pump and some solar panels would be a great way to ensure heat in the winter and cooling in the summer too. I’ve often dreamt of a bungalow like that. Somewhere I could even get outside of...

Nice work Team France :thumbup:

Thanks for the tips. I will be getting some more earplugs soon so will report back. For the daytime when it's noisy I am similar to @Evergreen in a multiple step approach. I have in ear headphones with comply foam tips which isolate well and then ear defenders over the top, then play music or...

When I was first ill I was bey unsure about a diagnosis of ME/CFS partly because while I was struggling generally with ‘energy’ or ‘stamina’ I had a series of what felt like sharp ‘crashes’ rather than what I understood of as PEM. And I didn’t have sleep problems. Things changed but I’ve often...

Medication Use and Symptomology in North American Women with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, A Pochakom, G Macnevin, RF Madden, AC Moss, JM Martin, S Lalonde-Bester, J Parnell… Background: There are no known curative treatments for myalgic encephalomyelitis/chronic...

Most of the information on their website is formatted more as investor information and press releases. So there isn’t a great deal to go on, but they do seem to be working with the NHS to trial their ‘platform’...

Not with the normal cycle or shift no. I do have trouble in the summer, some of which is the impact of the earlier morning sun but also the warmer weather, both of which negatively effect sleep.

I did have some hope for this plan, have tried raising it with my MP, etc. But it’s not looking positive is it. To be honest I wouldn’t mind if they closed all the specialist clinics. They’re a waste of time in my experience and used as somewhere to shuffle people off to, part of the...

Thank you both! It’s really useful to have this insight and pointers to more information.

I seem to have accidentally triggered a philosophical discussion! @EndME put it well though I think and overall I support their view. Does someone who is mild have ME/CFS if they’re having a good day and functioning near normal? Do people in a sort of remission, even if temporary have ME/CFS...

The basis for this paper seems to be the paper in this thread Metabolic features of chronic fatigue syndrome, 2016, Naviaux et al I do remember lipids more generally cropping up in a couple of other papers though so maybe there’s something here? Replicated blood-based biomarkers for Myalgic...

I just wanted to thank people for continuing to slog away at this.

Same. It always messes me up, never used to.

So there are four groups control group model group with no genetic changes NC (Model) model group with the PK2 gene knocked down/with reduced expression (Model + PKM2-KD) model group with the PK2 gene over expressed (Model + PKM2-OE) The title and hypothesis is “PKM2 accelerated the...

There may be a contradictory findings or wording in the paper. Something which was flagged in one of my LLM generated summaries I listen to and I think can be seen in the abstract. I need to check the paper to confirm though and can’t quite get my head around it atm but… Here’s some quotes from...

CFS is persistent fatigue so inducing persistent fatigue is CFS is a sort of logic I guess? They do seem to have invented a new way of torturing mice anyway. While I’m very wary of their definitions of this being CFS let alone ME/CFS, trying to understand induced fatigue seems a fair enough...