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Conclusion: I'm thinking maybe a tad judgmental and highly doubtful. Relevance: Perhaps to several characters from The Donna Reed Show?

I'm not sure the authors are clear on what is meant by personality traits. In particular, if someone is in pain, and he tries to avoid doing things that exacerbate the pain, that avoidance does not qualify as a personality trait. It qualifies as a subset of common sense.

Also, high education level, multiple partners, fans of Ann Rice, stubborn people, men who are fond of bow ties, woman who are fond of bow ties, low frequency of GP contact, people who enlist in the armed services, draft dodgers, and everyone from the US state of New Jersey.

Covid crosses the BBB. Then what? Does it have a tropism for different parts of the brain? Is it indiscriminate as it ravages like 9th century Goths? Do symptoms mirror neurosyphilis or neurolyme? What time frames are involved? What happens in 6 months? 6 Years? Ive read atrophies of grey...

Sounds to me like they're clueless and they elected to punt. Persistent muscle soreness? Interesting that they characterize Covid as an infection and not so ME/CFS. They do seem to reduce ME/CFS to pain with fatigue, so, you know, clueless. Give the ball to someone else.

What are case reports if not a trial run for a clinical trial? Besides, I am a bit familiar with this sort of NIH group think. Three months is like code for long-term. If this were an abx treatment RCT, three months is a lock for whatever result they want.

CDC really is more advertising agency than medical research entity, right? The NIH is the research arm, or at least what passes as research.

I think I will apply for their research roadmap working group. Hope my name doesn't throw up any red flags. It might. I've some history there. :)

Six patients for three months. Six. For how long again? Three months? In what fantasy world is three months "long term"? I think of long term from the patients' perspective, which means years. I'm not sure three years qualifies as long term. Maybe. Thirty does; thirty would qualify. Three...

"However, we suspect that in ME/CFS the endothelial dysfunction is related to an abnormal immune response...." Why abnormal? Why not simply an immune response. There are several infections that can target endothelial cells, not the least of which is Covid...

So, I have ME. I just got over Covid a week ago. Some of my symptoms right now are imo covid-related. They're different than my ME/CFS ones. In a month or two or six, could those symptoms qualify me as LC, and who in the world would make that call? I also qualify as chronic Lyme, but there...

Sometimes it's the system, or part of it, that renders the illness invisible. A 1983 paper on Lyme, for example, purportedly had that very affect by reducing subjective symptoms to "minor" status. The result was that if clinicians could resolve the handful of overt "major" symptoms, the disease...

Can pwME get long covid? Anyone looking? I'd suspect Hanson or Levine, but don't really know if anyone has published anything. But I'd be curious to see that math.

Good to see they're not rushing into anything....

Until we can demonstrate conclusively that there are absolutely no Covid remnants in any patient who presents with persistent symptoms, "causal" studies such as this cannot rise above definitional white noise.

Oh good. Statistics and semantics conjoined in a single piece highlighting two confusing and contested diseases. What could go wrong?

"There is zero credible evidence that she ever had Lyme Disease (by her own admission, she tested negative based on established, mainstream CDC criteria), let alone a chronic manifestation that was alleviated in any way by multiple rounds of long-term antibiotics, which have been decisively...

I can appreciate this sentiment. But there may be rare or fringe cases that might not be considered as such if they are tested for - and found - more often. When my wife tested positive for her rare channelopathy gene she was only one of less than 100 in the entire world. Five years later and...

Perhaps an alternative co-thread might be common diseases with inadequate diagnostics that could be misdiagnosed as ME/CFS. :)

Babesiosis is considered rare. It can mimic ME/CFS. Ditto for B Miyamotoi, which is a relapsing fever and I believe is still considered rare. I second channelopathies.