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Other prior studies suggest persistence as a factor. Wonder why I feel the influence of a rheumatologist in this. Wonder which group from Johns Hopkins. Oh, and why is someone from AstraZeneca out of the UK involved? As they do in the various stages of Lyme. So I think this could represent a...

Mentions Long Covid and Fibromyalgia.

This is a fun conversation, but I am taking up too much oxygen in the room and for that I apologize and will stop.. I'm not sure much of the ME/CFS paradigm aligns with any known duck relative to many of its symptoms; this may also hold true for neuro aspects. There is precedent for this as...

Yes, to both @Trish and @jnmaciuch . These observations may be spot on. Our deficits may be temporary, they may be rooted in different mechanisms than in other manifestations of cognitive difficulties. All I am saying is that the cognitive deficits that appear in some pwME are cognitive...

Agreed. So you (and he) are suggesting our intellect is intact, but we have "distractions" that seem to inhibit or impede what would otherwise be a fine-working intellect? Have I got that correctly? This seems unnecessarily convoluted. Wouldn't a simpler explanation be that something is...

I'm struggling with this arithmetic, so please bear with me. On the one hand we have pwME, some of whom experience more pronounced deficits in intellect. But they don't disassociate, they don't hallucinate, their cognitive problems are more or less limited to executive functions, to things...

We have so many symptoms, but there is no standard intensity with which we all experience them. We are all unique in terms of how each symptom manifests. This is true in terms of duration and frequency and intensity. It's true for what triggers PEM, too. I think pretty much all pwME understand...

Some pwME have intellectual impairment. If anyone is going to characterize our disease, this fact in my opinion should be part of the characterization. What should not be part of the characterization is saying there is no intellectual impairment among pwME. That would simply be incorrect and...

People with ME share core diagnostic requirements. Things like unrefreshing sleep, PEM, OI, etc. They all have these factors to varying degrees. Same is true for things like balance or pain or exhaustion. Some people are in so much pain they can think of little else. Some people are so exhausted...

Merged conversation This smacks of opinion but it is framed as fact. Please remember this is a science forum.

FYI, purportedly there is acquired periodic paralysis. This is - as is the case with typical pp - supposedly temporary or intermitant. Not much, relatively speaking, is known about it because no money is thrown at it because it effects so few and, for the most part, we are a selfish and...

Alternatively, they could offer support for proximity playing a role in familial clustering of ME/CFS. I have not read the entire paper, and really don't want to revisit XMRV anyway....

I used to think heart rate or blood pressure had something to do with PEM. It's easy to fit either into "physical" or emotional induced PEM. It's not as easy when purely cognitive PEM is on the table. But I think I can differentiate cognition when laying flat vs cognition when sitting up. I read...

I would be careful here. Making sweeping generalizations is seldom wise, but where it concerns pwME, it is even less so.

There was a school of thought out of Australia that suggested ME/CFS was in at least some cases a channelopathy, or involved a channelopathy. I am struggling so excuse this layperson's attempt to describe: Channelopathies refer to ion channels in muscle cells that fail to one degree or another...

Brings to mind channelopathies and periodic paralysis variants.

How would that relate to the brain? Do we trust this? It's hard when you read something sometimes..

If I could triage my physical rehabilitation, I'd start with my brain. Unfortunately, I am not optimistic all the brain problems will resolve with whatever treatment. I fear for some pwME, there may be permanent damage, and cognitive problems might remain, even if the lion's share of symptoms...

I wonder why facial paralysis wouldn't be considered a biomarker. In some infections, rashes would be in and of themselves.

Idiopathic? I thought Bell's palsy was tied into a handful of viruses and bacteria, e.g. herpes variants and borrelia.