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For this one, frequency of total NK cells wasn't different between multiple myeloma responders and nonresponders in either bone marrow or blood. What was different was higher proportion of CD16+ NK cells and lower TIM-3+ NK and HLA-DR+ NK cells in the bone marrow in responders. I'm not sure if...

It'd would be good to know how correct this is about, for example, spleen plasma cells being mostly non-specific. That's just what I remember from an intro to immunology textbook. Maybe high IGHV3-30 from the other studies might also point to overly high levels of non-specific innate-like...

Maybe, but if blood count was a good proxy for bone marrow count, I'd expect studies showing that blood NK count in multiple myeloma correlates with improvement from dara, but I haven't seen such a study. I don't think it's impossible. Maybe the body can deal with the antibodies from, say, 1000...

I think also: 1. Faulty T cells being the problem 2. Faulty NK cells being the problem 3. Some other cell that expresses CD38 being the problem. I don't think they say anything about exact levels of protective antibodies, just that they're still at protective levels at 12 months, so maybe...

The association of fatigue and pain with cognitive test performance in patients with myalgic encephalomyelitis/chronic fatigue syndrome Joukje M. Oosterman, Marieke van der Schaaf, Willemien P.E. de Kleijn, Tanja A. Kuut, Inti A. Brazil, Hans Knoop Highlights • Fatigue severity was the...

Preliminary evaluation of a cognitive rehabilitation intervention for post-COVID-19 cognitive impairment: A pilot randomized controlled trial Jacqueline H. Becker, Eric Watson, Nadia Zubair, Fernando Carnavali, Emilia Bagiella, David Reich, Juan P. Wisnivesky Background: Despite the profound...

Experiences of living with long COVID during childhood and adolescence: a qualitative study from the child’s perspective Emmy Lillieberg, Per Ertzgaard, Eva Fernlund, Karel Duchen, Patrik Rytterström & Charlotte Angelhoff Background In February 2023, the World Health Organization (WHO)...

I'm not sure. Maybe higher dose? Here's the paper you linked to: Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma, 2017 Fig 2B They used 16 mg/kg in multiple myeloma for that chart. The ME/CFS study used 1800 mg. I'm...

What I see is that recovery begins sometime after 9 months (in the 7 that have data past 9 months). Maybe one participant's NK count went back up at 10 months, but they weren't tested again until 15 months, and maybe another's count didn't go back up until 20 months, and that's when they were...

At 9 months I still see 3 participants lower than the previous point. At the next point, they all increased, but note that that point spans a very wide range spanning 6 to 12 months after the 9 month test. Also, this shows data for only 7 out of 10 participants after 9 months.

Genome-wide association study of adolescent-onset depression Abstract Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide...

Immunological and non-immunological features specific to Long-COVID: multiple overlapping aetiologies and potential biomarkers Frederique C Ponchel [Line breaks added] Abstract Long-COVID (LC) is a serious clinical condition characterised by debilitating fatigue together with a wide array of...

It looks like stimulants are both recommended and not recommended.

See discussion of Amatica's analyses related to ROCK1 protein here: Rock1 protein

I can't see this being more useful. We currently can see that the "substantial bulge" is four or so points next to each other now. If they were all squished together on the left side, there'd be a more or less a thin line on the left side, with a bulge still in the same location but where it's...

I'm not really understanding in what way it's misleading. The number of points in the left plot is clearly visible here. I think the difference in cohort sizes would be less clear if the points were squished together.

Noting that they do say the exact date in Milivojevik/Lipkin 2020:

We've moved some posts about smartwatches to a new thread: Smartwatches for health monitoring

BBC: 'Play explores life with a hidden chronic illness' 'YAWN, written and performed by Hollie Christian-Brookes, a former Bath University student, charts the emotional and physical toll of Myalgic Encephalomyelitis (ME), also known as Chronic Fatigue Syndrome (CFS).' 'Having played at the The...

This thread's study, plus the following two: The first one isn't exactly the same as the other two since they couldn't discriminate between IGHV3-23 and IGHV3-30, and the ME/CFS group seemed to have individuals with both very high and very low amounts of the combination of these gene segments...