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No I must have misremembered if they're saying they plan to add more males.

I'm not sure exactly what you're referring to. But I think she said they haven't tested in men yet. Edit: Or maybe they did test some? The summary slide says they plan to increase sample size for males.

I assumed the bar plot shows fewer than all the tissues/organs they looked at, and they just picked and chose the tissue groups and bones where there appears to be a pattern (even if not quite significant in some), plus three organs just to demonstrate that it's not high everywhere. Would they...

Jaime Selzer posted several screenshots from his talk on Bluesky, but I think you need to be logged in to see. Is this the one:

In my intro to immunology reading, I thought what happened was that naive B cells that do not match an antigen or do not receive co-stimulation from a T cell die by apoptosis. Are T cells actually directly killing B cells?

Editorial: Dormant Cancer Cells, Cancer Progression, and Post-Acute Sequelae of COVID-19 and Influenza Dinah V. Parums Abstract Since the COVID-19 pandemic, vaccine uptake has fallen, and awareness of the long-term consequences of respiratory virus infections, particularly long COVID, also...

See thread for trial protocol: [USA] A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID [ADDRESS-LC]

Previous thread: BioVie Awarded up to $13.1 Million in Funding from U.S. Department of Defense to Evaluate Bezisterim (NE3107) for the Treatment of Long COVID

A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID Brief Summary Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection.This study aims to evaluate the effects of NE3107 on...

In the screenshot I posted of the bar plots of the data for tissues in everyone, it looks like there may be a signal in the bone as well. In the pelvic bone and maybe also in the femur and lumbar bone marrow, though not significant for the last two. Does it change things for there to be signal...

I don't know about the two specific people in the images, but in the demographic data screenshot for all 13 women, for the multidimensional fatigue inventory (MFI) score it says 86.62 for cases and 32.08 for controls. From a paper:

Upper gastrointestinal symptoms and Gulf War Illness in a clinical cohort of US veterans: a retrospective, cross-sectional study Abdelrahman Yousef, Sarah T Ahmed, Theresa H Nguyen Wenker, Alice B S Nono-Djotsa, Stephen H Boyle, Elizabeth J Gifford, Deeksha Malhotra, Helena Chandler, Sandhya...

No, I don't think they have tried in ME/CFS patients yet (maybe not even any humans). She talks about how they are developing the GPR84 tracers and gives rationale for using them (more specific to microglia and macrophages than TSPO). She said they're at the stage where they're about to...

Note that the two PET screenshots are of two different pairs of matched participants (out of the 13+13 that were studied). I'll edit my post to make it clearer that it's two cases.

Did you see the screenshots I posted earlier? Aren't those the PET images?

On its surface, I also both instinctively want to say things like this ("it's not depression"), and also find it strange when I see others say things like this. But I think it's because the meaning when this is said is somewhat ambiguous. The person with ME/CFS is saying "What I have is...

Screenshots of the data from the full body scans with the TSPO tracer: 34 year old case and 36 year old control 51 year old case and 50 year old control Edit: Added labels above PET images.

OpenAI (makers of ChatGPT) mentioned Derya Unutmaz and quoted his tweet about using AI for ME/CFS research. https://twitter-thread.com/t/1962938974260904421

Do self-perpetuating B lymphocytes drive human autoimmune disease? Jonathan C W Edwards, Geraldine Cambridge, Vikki M Abrahams Published: 1999 [Line breaks added] Abstract Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are...

I know very little about the specifics of how all these drugs work. I think ideally you'd test with a drug that reduces neuron firing relatively globally in the nervous system since we wouldn't know what specific neurons or regions might be more important. A person would do an intense exercise...