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While I'm all for free speech and being able to freely point out issues with papers, I just want to at least acknowledge that PubPeer can at least theoretically be weaponized against authors. Moderators on PubPeer don't thoroughly check every comment for accuracy. So if someone had a grudge or...

With too low, I was thinking it could be the body not keeping up with normal axon repair/replacement/plasticity processes that maybe are supposed to happen after exertion.

I've only quickly skimmed, but the axon guidance gene set being most significant stood out. This was based on proteins measured before exercise on day 2. The negative enrichment score indicates that proteins in the pathway were downregulated. Figure 4: These are the leading edge genes in the...

I only read the abstract, but thought it might be kind of interesting since I would say S4ME's discussions often seem to fit the "post-publication peer review" idea.

An expert criticism on post-publication peer review platforms: the case of pubpeer Abstract While traditional peer review offers advantages in academic publishing, it is often hampered by significant weaknesses, leading to frustration among many authors. Scientific discoveries after...

My mistake, I just looked at the video from last year, and it's the same plot. Timestamped link.

Some notes on Morgane Bomsel's talk: This is about patients with symptoms more than 6 months after acute COVID, and median 16 months after. She showed a plot of SARS-CoV-2 detected in megakaryocytes which is the same as the one shown last year: Around 30% of megakaryocytes in long COVID have...

I might be misunderstanding something, but doesn't NIH have a budget of around $1.5 billion for long COVID over about a decade? https://thesicktimes.org/2024/12/12/nih-announces-147-million-in-additional-long-covid-research-funding-new-budget-details/

Abstract 4344995: Prognostic value of cardiac computed tomography delayed enhancement in individuals with post-acute sequelae of COVID-19 [Line breaks added] Introduction/Background Post-acute sequelae of COVID-19 (PASC) have been recognized as serious complications of SARS-CoV-2 infection...

Abstract 4369416: Impact of Long COVID on Physical Activity and Sleep: a Matched Cohort Study using Wearable and EHR data From The All of Us Research Program [Line breaks added] Backround Long COVID (LC) is associated with negative health effects, but its impact on health behaviors such as...

As far as I can tell, this is just a poster abstract. There's no more text behind a paywall.

FYI, the full texts of paywalled Nature papers are often available on PubMed Central: https://pmc.ncbi.nlm.nih.gov/articles/PMC7572537/

There's a website to explore a subset of the papers summarized so far: https://laion.inference.net/embeddings I typed in "chronic fatigue" and clicked on one at random out of 8 results, and it happened to be authored by @DMissa. I don't see a way to share the link to the summary directly, but...

"Project OSSAS: Custom LLMs to process 100 Million Research Papers" November 11, 2025 "Today, we’re introducing Project OSSAS in collaboration with LAION and Wynd Labs. Project OSSAS is a large-scale open-science initiative to make the world’s scientific knowledge accessible through structured...

Effectiveness and safety of exercise therapy in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A meta-analysis Zhenya Wei, Heying Wu, Chong Cui, Zixu Wang, Huazhong Xiong, Fujia Song, Jixiang Ren [Line breaks added] Purpose To promote the development of new...

As far as I can tell, they didn't actually cite the 35 m minimum clinically important difference in the present paper. That was a quote from the preprint: Resistance Exercise Therapy for Long COVID: a Randomized, Controlled Trial, 2025, Research Square But they removed that mention of the...

Someone added a comment to the paper (scroll to the bottom): Misleading interpretation of the null results? First paragraph:

Reminder that sharing the full text of the paper on this thread would be breaking the copyright rule, and would end up being removed. Fair use allows sharing brief excerpts for commentary.

Fig. 1: Forest plots for significantly reduced tCho [total choline] in anxiety disorders.

Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a 1H-magnetic resonance spectroscopy meta-analysis Maddock, Richard J.; Smucny, Jason [Line breaks added] Background Anxiety disorders (AnxDs) are highly prevalent and often untreated or unresponsive to...