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The methods are fairly standard and combining results from several big DNA studies is routine (and papers doing this pay attention to any differences when drawing conclusions). The biggest variable is the "genotyping chip", the device used to identify DNA differences at around 1 million...

The latest I have heard is that results (not final, published results) might be seen before 2024. The whole point of these big DNA studies IS to find out what is happening in our bodies. Take a look at the latest DecodeME blog which gives a couple of examples and makes the key point that genetic...

They used the PHQ-9, which was developed for screening healthy populations but which awards points for core ME/CFS & long covid symptoms including sleep problems, fatigue and problems concentrating. The PHQ-9 is inappropriate for measuring depression in this population - the authors might well...

I hope the Mods won't mind me creating a thread for this blog, which looks at why genetic studies are so important. Posted for British Science Week. Decades on, and with over $100m spent on research (it should have been much more), we still don't know for sure any causes of ME/CFS. Genetic...

N is too small to draw any conclusions. But I agree, the approach is very interesting (and could also be applied to other biomolecules). I haven't read this paper but I have been extremely impressed by the methodological rigour in earlier Warren Tate studies. What we need now is a much bigger...

This is my analysis on PR from 2016 of the Pendergrast/Jason study and others, including looking at biases https://forums.phoenixrising.me/threads/jason-et-al-housebound-versus-nonhousebound-patients-with-me-cfs.44330/post-724544 Short version: The study provides support for a 25% rate of...

Three more remarkable poems from Veronica. Her best yet, in my view. Bulwark: To Jane Eyre On being housebound: ...far from That turquoise line of beckoning, where sky And earth embrace. I’m scared the arctic tern Caged in my ribs will break its wings over A view it cannot see, while walls...

And there’s nothing like a big pot of money – in this case about £25 million – to get the attention of researchers from outside the field.

They’ve been quite a few studies since then and it does seem to be reasonably good for 25% equals housebound. Eg Pendergast

Why is this is a thing worthy of mentioning in the abstract? It is why almost all people consult a medic, regardless of their illness. I wish medics and researchers shared patients' motivation to search for physical mechanisms.

Not as far as I know. Taking any medication won't affect your DNA. Possibly if you were on strong chemotherapy that causes severe fatigue, but I can't remember if that's in the screening questionaire.

:rofl: Possibly the best quote about research that I have ever read.

I hadn't seen this posted anywhere else. Listening to it now. Focuses on the immune system. Yale's Akiko Iwasaki is always good on Long Covid even if the Guardian and the interviewer, Ian Sample, are not...

@Snow Leopard Nice analysis. If I've understood you right, you are saying the authors have shown decent antibody binding of GlialCAM (which could explain MS) but only weak binding against EBV protein EBNA1. And that this could just be because the glialCAM ab happens to bind EBNA weakly - not...

I can't access the paper. Here's the Work and Social Adjustment Scale https://www.networks.nhs.uk/nhs-networks/regional-mental-health-commissioning-networks-portal/documents/wsas.pdf "People worried more when their ME/CFS caused worse problems with being able to work, socialise, manage a home...

DecodeME has tweeted about the relevance of this to ME/CFS. And the MRC retweeted DecodeME...

A new paper in Nature says: Here we demonstrate high-affinity molecular mimicry between the EBV transcription factor EBNA1 and the CNS protein GlialCAM, and provide structural and in-vivo functional evidence for its relevance... Our results provide a mechanistic link for the association between...

Comments For me, the most striking thing about this well-done study is that it finds two biologically coherent groups of symptoms among those with long covid: one a post-infectious ME/CFS and POTS-like cluster, e.g fatigue, brain fog, memory issues and palpitations. the other a chest-based...

This excellent Scientific American article covers the paywalled article. Some comments, mostly based on the SA piece. Study method Researchers had long suspected a link between MS and EBV but it's hard to study the connection when 9 in ten adults are already infected with the virus. This came...

New member-only thread DecodeME - which studies should we be able to compare results with?