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This is an answer from the Secretary of State/Department of Health and Social Care - the Westminster system seems to allow for the appointment of under-Secretary of State but it's still the answer from the Secretary of State/Department. In practice the minions (civil servants) draft the replies...

"Id Dr Busse had been appointed as chairman presumably there is a high chance that the result would have been different. That makes the system fragile." As a (very) general rule the proposed position/outcome is consulted upon and the hope is that the consultation should reduce the risk that the...

Thank you for this. I agree surely NICE could employ scientist graduates to do this "I think it would be fair to ask technical staff to search for studies and document a list of features ----." E.g. is the study blinded, does it use object outcome indicators [FitBit or whatever] ---? Hope...

I think we should challenge the recent NICE decision to stick with using Cochrane*. I was thinking of writing to the APPGs on ME/CFS (title?) and Coronavirus (title?). If the NICE review re CFS guidelines found the available studies to be "low and very low quality" and Cochrane found them to be...

I don't keep up with this stuff so I may be inaccurate here. The whole thing seems bonkers* we can see NICE aligning themselves with Cochrane but the NICE review has just shown all of the ME/CFS studies were "low or very low quality" and Cochrane presumably marked these as "medium" - how is...

I assume that problems re lipids would have turned up in one of the metabolomics paper e.g. Jonas Bergquist published a study a few years ago. Need to go and have a look at previous studies. EDIT - added text - there's a good analysis by @Simon M here re Maureen Hanson/Susan Levine's recent...

With such debilitating illness I'm hoping something turns up on the GWAS study - that way there'd be more reliable clues regarding where to focus research.

The use of a very basic form of actimetry (activity monitoring), i.e. FitBit, in this study seems to challenge the dependence on questionnaires in UK Government studies. Then again it's not as easy to manipulate the results to show the intervention worked - hence the continued reliance on...

@Mithriel just noticed your profile picture and that bear looks like it was introduced to a not very friendly porcupine!

Wow I'm conscious of how complicated this is and your grasp of the material - thank you very much for this detailed response. I think I read Cort's article when this all kicked off (2018); I'll re-read it.

Yea but if you were asked to provide the title then ---- How to build a career out of scamming the public into paying for flawed research --- muppets indeed i.e. the public/public representatives/system which continues to fund this crap.

I recall @Snow Leopard post here re Fluge & Mella's recent paper*. Is this theory related to HPA axis and if so is this at odds with Fluge & Mella's recent paper? *"Another key finding buried in the text: Corticosteroids* did not seem to be involved, since they depended on age and BMI instead...

I noticed they used an objective outcome indicator* - interesting to see the raw data --- is it available/has anyone had a look at it? *"Secondary endpoints included: ---- (ii) FitbitTM metrics (activity, HR, and sleep), continuously monitored throughout the trial;---" @Jonathan Edwards has...

Yea that's a common concern i.e. how do you get adequate controls to assess the affect of sedentary behaviour?

Weird my wife takes carnitine (post antibiotic) and my daughter has disabling fatigue. Carnitine "transports long-chain fatty acids into mitochondria to be oxidized for energy production" [Wiki] so I'm guessing that if you increasing your dependence on fatty acids [for energy], i.e. due to...

Yea but we can see what a shambles you get if you don't employ reviewers who aren't sufficiently knowledgeable and/or have a conflict of interest. If you look at the cost of the review (using appropriate reviewers) and the total cost of the service [on a UK basis] then the cost of the reviewers...

Yea we maybe need that book @Jonathan Edwards --- has the system learned nothing from this debacle?

Yea, sure others picked up on this from Trudie Chalder: Chalder, the CBT practitioner, said it was unhelpful to see the debate in black and white. “This kind of dualistic thinking – it’s either psychological or physical – is not particularly helpful when you think about any disease. ---"...

Yea Ron Davis got (5 year) NIH grant back in 2018 - so maybe this is an early indication of where that it is going [Fluge, Mella --- are part of OMF]. Great explanation of HLA from @Simon M here...

Didn't OMF (Ron Davis?) get a NIH grant to sequence HLA? Could have been KIR sequencing of course. Perhaps @Ben H could provide an update? @Jonathan Edwards views might be interesting re this paper EDIT - added text - if we're back to proposing autoimmunity then this technique could...