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Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling [https://www.nature.com/articles/s41598-018-34166-4]

"King’s College London, which touted the findings in a press release, has licensed the web-based CBT program to a private company. The company has received approval to market the program in the US and UK. --"* So they get public funding [Department of Work and Pensions funded PACE and the...

I have a neighbour, who is a medical doctor, and he recounted how, when he was working on a ship - decade ago, he found a batch of vaccine sitting out in the sun - in the Caribbean. So he just dumped it. In the real world I suppose these things can happen. Hope you get it sorted. Haven't seen...

Yea it would require them to own up that while there was an aspiration the (delivered) reality was crap - @Jonathan Edwards comments, re whether you could ever develop a metric (like Cochrane) to evaluate research, come to mind. So they won't climb down and say this was all rubbish.

@Snow Leopard posted* a link to this paper a few weeks ago [https://www.medrxiv.org/content/10.1101/2021.05.22.21257658v1]: "Conclusions After 2 doses of either vaccine there were only modest differences in vaccine effectiveness [Pfizer vaccine versus AZ] with the B.1.617.2 [Indian] variant...

Makes you wonder - why would scientists own up?

Sadly I have to agree. I was a bit shocked when presented with evidence that public inquiries can be set up to provide a certain outcome. I wouldn't rule out an inquiry finding that the establishment behaved responsibly. Look at the Lancet; I'm an outsider, but the Lancet looks like bona fide...

Realistic but maybe 2-300!

I'm a fan of Warren Tate (the second "expert") i.e. since his daughter suffered from ME/CFS - I think her health has improved. Speculation - Perhaps Warren's thinking of the tryptophan ("trap") theory i.e. (I assume) lower kynurenine production would lead to increased susceptibility to...

Re "This report is independent research. The views expressed in this publication are those of the authors, not of the Linbury Trust, the NHS, the National Institute for Health Research or the Department of Health and Social Care." As a body appointed to allocate public funding to research (i.e...

As you flagged up previously this is funded by National institute for Health Research Senior Research - "funded through NIHR, which is designed to do bad research for political convenience--"...

Or at least rebrand the crap you're delivering i.e. if the old stuff has been found not to work!

Not something I'm a proponent of i.e. changing pieces of genome without good evidence. Just pointing out that it seems that switching off/downregulating diseases causing/promoting genes is no longer science fiction albeit that the issue of how to target specific cells hasn't been solved.

BBC Inside Science had a feature on use of CRISPR to treat this genetic disease. Apparently the fact that it affected liver cells made it easier i.e. since liver cells purify the blood and thus take up the lipid nanoparticles containing the RNA. Other cell types will be more difficult to target...

CRISPR has been used to treat a rare genetic disease i.e. by injecting lipid nanoparticles containing the RNA into the bloodstream. OK we don't know the cause of ME/CFS and/or whether switching off genes would help but the technology interested me...

I've only scanned the paper for a few minutes and my understanding is very basic. You may recall the recent discussion on a new technique ("REAP") to test for autoantibodies*; here's an extract: "Similarly, technologies that rely on the use of peptide fragments are not able to detect...

Yea and the design of the system means that academics need to publish so many papers/get so many points --- so I guess gaming the system [EDIT i.e. publishing poor quality studies with subjective outcome indicators] is incentivised!

Yea and (to me) ludicrously there are comments here (UK) about not wanting to be like Australia!

Yea I recall this "There was no significant improvement on any of the trial’s objective measures, such as numbers returned to work or levels of fitness." [https://journals.sagepub.com/doi/10.1177/1359105317703785 by Mark Vink]. So why not even use these objective measures of whether an...

My view is that there have been clues to how you assess the outcome of interventions for some time. E.g., as someone with a slight interest, I'd come across a study of American soldiers, who'd been in one of the Gulf wars, which monitored their phones --- moving around/not moving around ---...