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I was wondering who the leading research groups are re T-cells - Jo Cambridge (UCL)? @Michiel Tack

I really haven't followed this @rvallee but I came across this on the web* - sort of illustrates the problems the EDS folks are up against. I.e. academic system needs funding (your research group doesn't bring in funding then it will be wound up) and the Government needs cheap, and popular...

Partial memory! Thank you; here's the quote I was thinking of: "When I [ @Jonathan Edwards ] acted as MRC advisor this recent time around the GWAS project was the one thing that looked worthwhile, apart from maybe some actimetry studies."...

Thank you. I've noticed that you support the genome-wide association study (GWAS) i.e. since it may be a way to understand the underlying cause of ME. Chris Ponting's has received NIHR, & MRC, funding for an ME GWAS. I think you mentioned that there were some other interesting (NIHR?)...

I assume I'm missing something here but wouldn't it be better to try to understand what the underlying problem is and treat it? E.g. if there's a shed load of money, to investigate an apparent case of MUS - say in the US or a wealthy country where money is no object - and it turns out that MUS...

I think we might have better government if we had a PR system --- 44% of the vote should get you 44% of the seats not an 80 seat majority. As for the resulting pooling of MP seats; I've found a previous MP to be pretty useless so having a pool to choose from seems OK. But yes people were happy...

Emphasises how much better the situation is in Australia, New Zealand ---. Still I think they have to go for 1 dose strategy --- it might be enough to reduce then number of hospital admissions --- whether people with only 1 dose will still be at risk of serious infection (requiring...

Thanks I found it and yes there are some important qualifications: Vallance (El Pais): "in practice it [efficacy] will not be as high [89% - trial data], although not as low as suggested [33% - from Israel]---" Believe it or not they also quote "Matt Hancock" who acknowledge that they still...

Sadly I agree with everything you said and if I was better informed then I'd support it even more strongly. My neighbour (a medical physicist) has pointed out to me that bangs for bucks the NHS delivers an incredible amount - an acquaintance has pointed out that compared to Slovenia the UK...

Interesting, I heard the interview with Patrick Vallance (originally broadscast on Sky - yesterday) earlier*, and he was talking about 89% efficacy after 10 days (single dose). Not sure where El País is getting it's info from. I hoping a vulnerable family member (50s years old) is vaccinated...

Yea things can grab public attention and therefore the attention of politicians (& thereby funding) i.e. Long covid. Plus there's a concern about how big Long covid could be. I don't know how to do double quotes but @strategist seem to hit the nail: "How not to make progress: constant...

Pfizer (official trial) data is for symptomatic cases - Israeli data is for PCR positive (un-symptomatic?) cases - would be worrying if people are still infectious as well as PCR +ve though.

Just occurred to me the UK is pretty much running an experiment on whether 1 dose of vaccine is effective. E.g. if you check the number of people who have had 1 dose and been admitted to hospital after 1 month and before the second dose is effective --- maybe I've picked this idea up somewhere...

Only glanced at this but it reminds me of Bupesh Prusty's hypothesis i.e. ME is related to the effects of latent herpesvirus. Extract from paper: "The results indicate that fluctuating viral load, related to herpesvirus reactivation state, may play a role in ME/CFS pathogenesis, or might be a...

As @Snow Leopard said, I know this is speculative but I wonder what sort of clue/biomarkers would indicate this sort of problem?

I haven't followed this closely but the standard training for policy development involves an attempt to get you (policy maker) to approach the issue systematically. E.g. PESTLE - political, economic, science, technological, legislative, environmental or whatever. In this case Parliament has...

I contacted OMF and Linda replied "We have not looked into Campath". Perhaps they will look at it now. This seems an interesting way to get insight into the disease (ME) mechanism. @Jonathan Edwards

Thank you very much for your reply @Jonathan Edwards Re Campath-1H or something similar a bit like the Rituximab study then - wipe em out and see if it solves the problem. Is anyone aware of a large study of MHC sequencing in ME?

This is incredibly interesting @Jonathan Edwards - thank you very much. I wonder if there are any clues to the existence of the known (problem) T cell sub-groups in our genome and if another (problem) group could be identified via GWAS? What fingerprint would you expect to see in this type of...

Chris Armstrong (2015), and Fluge and Mella* (2016), have both pointed to increased metabolism of amino acids [specifically amino acids that bypass PDH/pyruvate "blockage" in the citric acid cycle]. Chris Armstrong is now being funded by OMF to look at protein (nitrogen) metabolism. Fluge and...