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  1. InitialConditions

    UK BACME ME/CFS Guide to Therapy 2025

    This has excellent anti-BPS sh*tposting potential, were we ever to go down that route.
  2. InitialConditions

    UK BACME ME/CFS Guide to Therapy 2025

    Yes, important point. Once you drop those fundamental tenets (deconditioning and fear avoidance), the whole house of cards collapses.
  3. InitialConditions

    COFFI - The international collaborative on fatigue following infection

    Yeah, they just renamed their Youtube channel. Nothing new.
  4. InitialConditions

    October 2025 IACFS/ME Conference

    Generally agree, but this one stood out. It sort of makes sense. I am big believer in focusing on the ME brain, and this seems like a good lead that could tie together seemingly disparate clues.
  5. InitialConditions

    Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus, Younis et al., 2025

    Yes, the lead author and Robinson are both on this recent paper from the Stanford groups: https://www.pnas.org/doi/10.1073/pnas.2426564122
  6. InitialConditions

    Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus, Younis et al., 2025

    Some press here: https://www.theguardian.com/science/2025/nov/12/epstein-barr-virus-appears-to-be-trigger-of-lupus-disease-say-scientists https://www.newscientist.com/article/2504061-strongest-evidence-yet-that-the-epstein-barr-virus-causes-lupus/
  7. InitialConditions

    Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus, Younis et al., 2025

    Editor’s Summary Epstein-Barr virus (EBV) has been making waves as a candidate driver of diseases like multiple sclerosis and Long Covid. It has also long been linked to systemic lupus erythematosus (SLE), although the “why” behind this link has not been defined. Here, Younis et al. provide...
  8. InitialConditions

    Visual Processing

    You've probably come across my threads here. I have quite severe visual processing problems. I have a bad case of 'visual snow syndrome' which is much more than seeing static. The most disabling symptom for me is afterimages (palinopsia). It's another condition that is not well understood and is...
  9. InitialConditions

    Review The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis 2025 Pillinger+

    Probably a worthwhile study. I don't think the average GP is clued-up about the different side effect profiles of anti-depressants, aside from the most obvious stuff. They just seem to have their own 'favourites' that they feel comfortable prescribing.
  10. InitialConditions

    Rapid recovery from all symptoms of severe ME/CFS by treating proprioception dysfunction syndrome: A case study, 2018(?), Da Silva et al.

    I don't really know enough about proprioception but it seems anything that invovles the brain's processing of signals can be affected, and this is just one part of the puzzle for some patients.
  11. InitialConditions

    Rapid recovery from all symptoms of severe ME/CFS by treating proprioception dysfunction syndrome: A case study, 2018(?), Da Silva et al.

    We've discussed this case previously here: https://www.s4me.info/threads/uk-dr-sarah-myhill.18699/post-372441 I can't remember the reason why it's in the Myhill thread, but there was a reason! EDIT: The author references Dr Myhill frequently in the website article, and it seems he may have...
  12. InitialConditions

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    Absolutely. Can tell it's AI based only on those few sentences.
  13. InitialConditions

    United Kingdom: News from Forward-ME Group

    Yes, they definitely need that too.
  14. InitialConditions

    United Kingdom: News from Forward-ME Group

    I am actually suprised FME is still going. It all seemed to fizzle to almost nothing a few years ago. I have just seen that their website is being redeveloped, which is good because it was awful. https://forward-me.co.uk/
  15. InitialConditions

    Do you have small fiber neuropathy (SFN)?

    There's a 'not sure' option, which will likely apply to many of us, especially in the UK where testing is sparse.
  16. InitialConditions

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Yes, this is what I was getting at. For example a combination of clinical tests aid diagnosis of Guillain-Barré Syndrome (GBS), but the overriding disease mechanism is unknown.
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