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Probably not much to see here. The study has a small sample size (27 LC patients) and the authors measured mitochondrial mass and membrane potential in 9 different immune cell types. That's 18 different comparisons, and it looks as if no correction was done for multiple testing. So it should...

Some questions were raised about the NHIS survey data in this thread: https://www.s4me.info/threads/cdc-data-brief-myalgic-encephalomyelitis-chronic-fatigue-syndrome-in-adults-united-states-2021%E2%80%932022-2023-vahratian-unger-et-al.36480/post-566066 In the 2023 NHIS survey, the prevalence of...

"The authors declare no competing interests." Jeff Wood's website: "I now work as a consultant to chronically ill patients, as well as to researchers and MDs who serve the chronically ill community." https://www.explorewithjeff.com/

See what you mean. They show that lupus patients have an increased number of these EBV-infected B cells, that these are reprogrammed, for example, to remain active, and present antigens, that they respond to antinuclear antigens, and that they can activate T-cells. But the smoking seems to be...

Sounds interesting, anyone able to share a copy?

Great news! I wonder what they mean with post-infectious disease: is it ME/CFS and Long Covid, or other diseases as well?

Looks like this is just based on self-reported questionnaires. Don't think one can study MCAS by just asking patients if they report certain symptoms or responses to treatment.

Here's the link to that previous study: Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients - ScienceDirect Looks like in other disorders such as schizophrenia, reeling has mostly been found to be...

Should we have a closer look at reelin? Both the blood marker and gene expression were increased in patients. This team has reported this before in LC. Here's the wikipedia description:

Do less viruses in the blood of ME/CFS patients mean something about their immune system or is the most likely explanation less contact with other people and therefore less exposure to viruses?

Think it might help if people are outspoken about this on social media. For example, regarding the 'ME is not CFS' debate, there is this sense that patient organisations and researchers conflate the two out of opportunism. And that the non-severe patients don't get the difference and are happy...

Hermisson et al. Pflegeanleitung für schwer- und schwerstkranke ME/CFS-Patient:innen Resource for severe ME/CFS in German (including automatic translation in English) Document | Thread

Suspect it was normalized. Either way, they report the minimal clinically significant improvement to be 10 points. So the mean improvement was lower than this, despite having no control group.

Made a brief summary of David Tuller's interview with Prof. Hughes: 1) Interesting interview of Prof. Brian Hughes by David Tuller. In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and...

Perhaps a bit off-topic, but was wondering if ME/CFS is like sickness behavior, why we don't see more loss of appetite.

Anyone has access to the paper and the main results?

They excluded the 7/37 participants who dropped out They do not compare results to a control group The participants received 40 sessions, which seems quite a lot And still the improvement was only 6.3 points on the SF-36 PF (a clinically meaningful improvement was defined as 10 points) So it...

That seems more like an argument that proponents of biomedical research would emphasize. Because biomedical research might provide a magic fix like a drug, vaccine or genetic test that could rid of the disease from society almost entirely. It holds much more promise in financial gains than...

No, it's often the exact opposite such as in psychosomatic theories on autism and schizophenia or articles blaming neoliberalism for making people sick, causing illnesses such as burnout and CFS. It's common for psychosomatics to emphasize societal problems as the cause of the illness. The...

Yes psychosomatic theory is sometimes used as a tool to justify withholding financial support from patients. But psychosomatics isn't about that and it was popular much earlier in other diseases and contexts not related to insurance or disability benefits. In the case of cancer and heart...