Search results

It was tough. I got sick in the pre-internet era (early 1990s). The GPs I saw either said it was nothing or "anxiety". I had no idea what was wrong with me for many years. All I knew was that each time I exerted myself too much, I'd get strange flu-like symptoms 24 hours later, lasting about 3...

This is a very old idea indeed. There are papers from the UK published in 1980s claiming the same thing. If breathing retraining fixed ME/CFS, we’d know about it by now.

I recall this study being discussed at great length. Perhaps it was on the previous forum.

Oh dear. LDN has been around for many, many years. If it worked for ME/CFS (and, reasonable to assume, Long COVID by extension) we'd know by now. Literally millions of Americans are on GLP-1 agonists; again, if these drugs led to reliable improvements in ME/CFS symptoms, you can bet this...

According to ambulance-chasing lawyers, yes. But not according to this large meta-analysis in JAMA Psychiatry: Results: A total of 27 of 144 RCTs meeting inclusion criteria systematically recorded suicide and/or self-harm-related events and included 32 354 individuals receiving GLP-1 RAs and 27...

Tirzepatide had no discernible effect on my ME/CFS symptoms even at fairly high dose. It's very effective for other things, as others have noted, but not for my core symptoms.

It's amazing how unpopular she is on Twitter/X not just among patients but also doctors. She has managed to piss off pretty much everybody which is delicious to watch.

This is actually shocking. Normally, journals endeavour to publish letters as soon as possible, while the original article is still "hot". In fact, major journals like NEJM have a time limit when you're submitting a letter on how long it's been since the publication of the original paper. The...

Good to see a negative trial published in such a prominent journal. I recall from the previous forum that colchicine was being prescribed to some ME/CFS patients about a decade ago by the Stanford people.

Thrilled to see this, @Tom Kindlon. So very deserved.

I had dry eyes and mouth in the early stages of ME/CFS. Positive Schirmer in one eye but negative for Ro and La. Over time the sicca symptoms disappeared. If anything, I would say I have excessive saliva production now. Reading Sjögren’s patients’ descriptions of their fatigue online, it can be...

This study embodies everything that's wrong with ME/CFS research. Inappropriate control group, inadequate sample size, irresponsible press release.

These are inappropriate generalisations based on being a visitor/tourist in two units. The reality is that if you have a "functional disorder" you will have your window blinds opened (which is difficult to cope with when you have light sensitivity issues), asked to attend the dining room for...

Anecdotal but a family member of mine died of dehydration/starvation caused by another disease and at no point did any medical doctor offer any suggestions regarding nutritional support, or any help of any kind really. I used to think it was just those of us with ME/CFS who got this sort of...

Supplementary Table 11: Cohen’s D estimates for BT, NMR, and proteomics

I've not had the chance to read the paper in detail yet so perhaps I missed it but I noticed in the DAG that physical activity was modelled as a mediator but I didn't see mention of body mass index being a potential mediator. The sorts of blood tests listed above are routinely performed on...

Any update on this that can be shared publicly?

42% increase in RELATIVE risk. These sorts of weak associations are found between childhood abuse and all sorts of medical conditions including obesity, cancer, heart disease, diabetes etc. There's a huge number of papers on this topic. The problem is that when these sorts of papers are...

DBT is dialectic behaviour therapy, a pseudoscientific talk therapy for borderline personality disorder. Like CBT and all other talk therapies, trials are typically conducted by people who are bought into the ideology and the results appear positive as a result of such biases.

Mirza case is quite similar to Maeve in that she developed intolerance to eating and drinking and died as a result. The hospital made her worse (psychiatric treatment, no medical feeding support) and she was sectioned under the false assumption that her mother was making her worse due to false...