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I just saw this Hungarian study and thought it was interesting. It is not about EBV but cytomegalovirus (CMV), which is very similar and closely related to EBV and can also cause mono/glandular fever (although EBV is responsible for 90% of the cases, according to Wikipedia). Large-scale...

Not ME/CFS but the Knives Out movies (the ones with Daniel Craig as the detective) are very popular so I thought I'd share. In the latest film, Wake Up Dead Man, there is a minor character who suffers from chronic pain. It is mentioned that it is a mysterious condition as doctors couldn't find...

Xinxin Cheng, Wenkuan Wang, Tingting Xu, Yanjie Wang, Xina Zhen, Wenxuan Man, Shuo Gao & Yonghui Yin Abstract To investigate differences in gut microbiota composition and short-chain fatty acids (SCFAs) metabolism between patients with Chronic Fatigue Syndrome (CFS) and Healthy Controls (HC)...

Article in Science Daily: Scientists discover first gene proven to directly cause mental illness Summary: Scientists have discovered that a single gene, GRIN2A, can directly cause mental illness—something previously thought to stem only from many genes acting together. People with certain...

Abstract Rare genetic factors have been shown to substantially contribute to mental illness, but so far, no precision treatments for mental disorders have been described. It was recently identified that rare variants in GRIN2A encoding the GluN2A subunit of the N-methyl-D-aspartate receptor...

Saoussen Naas, Dóra Kolozsvári, Luca Varga, Zsófia Tassó, Dániel Hammer, Erik Palmer, Lőrinc Polivka, Zsuzsanna Kováts, Veronika Müller, and János Tamás Varg Abstract Introduction Pulmonary rehabilitation plays a central role in the management of chronic respiratory diseases, including chronic...

P Gamillscheg, A Laszewska, K Hoffmann, J Simon, S Mayer Abstract Background Long COVID-19 patients experience a multitude of complex symptoms for an extended time, therefore often requiring increased medical care. Despite the global incidence of around 400 million (2023), little is known about...

Not BACME, but there was this physiotherapist from the University of Debrecen who wanted to recruit people from my group for a pacing up kind of study. It looked eerily similar to what we see here, with emphasizing that pacing up is not GET and rejecting the deconditioning theory. I asked her...

Donna M. Mancini, Danielle L. Brunjes, Dane Cook, Tiffany Soto, Michelle Blate, Patrick Quan, Tadahiro Yamazaki, Anna Norweg, Benjamin H. Natelson Abstract Introduction: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience symptoms of fatigue, dyspnea, mental...

by Miriam E. Tucker “We face a mismatch around physical activity between established medical practice and what the evidence actually shows. For decades, medicine has worked from the idea that physical activity promotes health and recovery…This underlying idea continues to underpin many...

Paper requested by @V.R.T.

Editor’s summary Lymphocytes, including regulatory T (Treg) cells, tune their metabolism to support their immunological functions. However, the molecular events controlling Treg cell metabolic reprogramming during inflammation are not fully understood. Using a mouse model of acute inflammation...

Apostolos P. Georgopoulos, Lisa M. James & Philip K. Peterson Abstract Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are...

I also saw this article about the response of Wallitt et al., so maybe they have sent out a press release (about their own response naturally): Myalgic Encephalomyelitis: Beyond Effort and Deconditioning 'In a compelling and much-needed scientific dialogue, a fresh reply has emerged in the...

Letter responses to the article in the Guardian: Failed by the NHS on chronic fatigue illness One of them is from Prof Paul Garner, Dr Maria Pedersen and Dr Alastair Miller (who would have thought...): "Milly’s exhaustion is typical of a group of conditions known as “persistent physical...

There have been several examples, for example with some organizations (Doctors with ME is something I remember but there were probably more), sometimes researchers or people doing their PhD come to S4ME and take scientific criticism very badly, one example was a questionnaire recently developed...

I do delete posts and even ban repeat offenders from my group when they obviously break the rules. But very often things are not so clear-cut, especially with newer users who may be just naive and inexperienced. I need to cut people some slack, because as I said, my group is quite young, and...

This is a constant problem in my group. It was started in the first year of covid and most people in my group are covid long haulers, so mostly newer patients looking for a cure, blindly trusting every doctor who just mentions "chronic fatigue syndrome" and not many people who already tried...

It is probably the test from the German Armin Labs, whose tests are known to overdiagnose people with Lyme (I have a memory from this forum that some very healthy journalist tried the test as an experiment once and it came back positive). A lot of people are told in alt med/Lyme circles that the...