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I was thinking that next year(s) might give some clearer answers about the antibody-hypothesis. - We already had negative results for Rituximab (which targets CD20), - The Norwegians and possibly also Scheibenbogen will test treatments that target CD38 - DecodeME will re-analyze the HLA region...

No, still re-reading some studies from this year. Thanks. Agree with the 'year of the gene'. Think this has allowed us to make a significant step forward in understanding ME/CFS, although it may still be a long road ahead. Feels a bit like laying the edge pieces of a big puzzle. Perhaps not a...

Some comments about the study here:

The paper writes:

EDIT: this is not a new study, the preprint came out in may 2025. There is an interesting new study with normative data for the 10-min lean test in adults without orthostatic intolerance. The data came from 112 participants of the LOCOMOTION study. The average heart rate change was an increase...

Background: Orthostatic intolerance syndromes such as Orthostatic Hypotension (OH) and Postural Orthostatic Tachycardia Syndrome (PoTS) are common symptoms seen in post-infection conditions and other neurological conditions with autonomic dysfunction. The 10-min Lean Test (LT) is an objective...

Did the same exercise again for 2025, and it looks like NIH funding for ME/CFS research keeps falling. There's some ambiguity about which projects to include (is it sufficiently about ME/CFS or not?), and we may have missed one, but the overall trend seems clear...

Thanks. Yeah in the r/aliens community, he made this comment:

Only 50 patients from a problematic cohort (which found a prevalence of 2.5%, about 5-10 times as high as similar studies). We have better sources now with DecodeME, so not sure it is worth digging into this.

Someone also pointed out that fibronectin 1 was increased in this paper in the ME/CFS group (red in the graph below). A previous Prusty paper also reported increased plasma fibronectin 1 Preprint - Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1...

Can you tell which one?

They found that ME/CFS patients had higher proportions of plasmacytoid dendritic cells (CD11c− CD123+, bottom right in the figure below). This is the immune cell type known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection as discussed in this thread: (1)...

There is also already a trial of Colchicine for LC, which found null results: Effectiveness of Colchicine for the Treatment of Long COVID: A Randomized Clinical Trial | Rheumatology | JAMA Internal Medicine | JAMA Network

Think the article is available at this link: https://www.nature.com/articles/s41591-025-04083-x.pdf The trial in question is called "STIMULATE-ICP" and will test "ivaroxaban, colchicine, famotidine/loratadine". https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272472 An...

They found lower butyrate, which is consistent with previous studies: Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients: Cell Host & Microbe Deficient butyrate-producing capacity in the gut microbiome is...

Yeah, not really a surprise, the way he romanticized his descriptions and case studies, things that were hard to confirm by others, it already gave the impression that there were many embellishments.

The researchers have a Dutch grant for ME/CFS research: https://www.zonmw.nl/nl/artikel/blog-een-behandeling-op-maat-met-immuunhandtekeningen-voor-mecvs Don't quite understand why this also showed an interferon difference between groups, given that it was mainly meant as a control condition.

Not really, because the co-occurrence of concepts is probably based on the text of the manuscript, not on the actual data. Suppose that several studies found a slight increase in metabolite X, but do not mention it anywhere in their paper, it's only visible in the supplementary data: would the...

Not far, think I didn't manage to do the FINEMAP.

The statistical tests used age as a covariate, but suspect that the data points shown do not take this into account. The HC group had a mean age of 31, and the LC group of 51. They also don't give much info about how the patients were selected. Suspect the study was done on patients in...