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Thanks! I've forgotten we had access to his response. Re-reading this a couple of years later, it seems his reply was quite unhelpful. His advice to dichotomise a continuous measure and then rating the certainty of a non-zero effect seems to go against basic statistical principles. Zero is not...

Yes I think the authors of the individual trials being included is a recognition for their data being used. The fact that Galsziou was senior author is more surprising. I hope he wasn't involved in the decisions about the update and its cancellation because as senior author he clearly was an...

anyone has the text of guyatts reply?

They simply measured ME/CFS-like symptoms" Yes agree, and it should have been done in the two studies you are reporting on!

His main arguments seem to be that recruitment was biased towards ME Association members or people affiliated with it and that it did not include patients who have recovered. But even if this was only a subgroup who had bad experiences with current services, it would be cause of concern (e.g...

Got the same impression when looking into psychosomatic theory for other diseases. It was usually presented as a progressive view and contrasted with genetic determinism. People like Kubler-Ross and Bettelheim believed that patients with schizophrenia/autism had no biological abnormalities...

Yes but even in this area it does not look impressive. The RECOVER study on ME/CFS post-covid did not include medical examinations so it was worse than the EBV studies we have.

Isn't that what happened in the US with the Long Covid money?

Quote from the retraction watch article: Back in 2019, we made an overview of guidelines and policies that referred to the GET review here: https://www.s4me.info/threads/the-influence-of-the-cochrane-review-on-get.11768/

Where did this funding come from? Was it a government grant that they lost or simply overall budget cuts?

Any articles on this because it seems like a strange decision.

Yes GRADE recommends downgrading for imprecision if the CI crosses the threshold of interest. Which is the case here.

I noticed that Lillebeth Larun has now responded to a comment: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub9/detailed-comment/en?messageId=446137675

Thanks for all the comments and suggestions. We have just posted the following poll on social media based on 3 options that we like the best thus far. Which name should we choose for our account and blog? 1) ME/CFS Science 2) ME/CFS In Depth 3) Science unravelled 4) None of the above (keep...

https://eprints.whiterose.ac.uk/164981/1/20200428ConversiondisordermisdagnosisGHPaccepted_combined_1_.pdf

Thanks. The data is in .raw filetype and have some trouble converting it to something like CSV or Excel. Anyone who has more experience in this?

This study is listed on MapME/CFS but it doesn't include the raw data from what I can see, only summary statistics of their analyses and modelling.

Just posting the main results here: The Japanese used next-generation sequencing (NGS) and got the following results: They also found that it was related to an infectious-onset and shorter illness duration (perhaps that explains why Ryback only seem to find it in the mild/moderate but not...

Any ideas at what this may point to? If it is not specific antigen driven expansion, what else might be causing this? And why would B-cell abnormalities make sense, as Nath said, if it is likely not related to a specific antigen drive?

Wrote a short section about this in our 2021 review of ME/CFS studies: