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Looks like they tested more than 2000 peptides in a cohort of only 30 cases and 30 controls (with ME/CFS patients in both cases and controls).

Here's what I think the study did: A previous Norwegian study found a link between HLA-variants and ME/CFS. Two were risk factors (more common in ME/CFS) and two were protective (more common in controls). This study checked how well these 4 variants bind to human-herpes viruses (HHV). Turns...

Thanks @forestglip!

Agree, and would be happy to collaborate on something like this. As I see it we would have to make a list of PEM statements that reflect how patients understand the concept and are useful to detect ME/CFS. We would then need to test these in ME/CFS patients and disease controls to check the...

Posts moved from main DecodeME thread. --------------------------------------------------------- Could you also check the region above TAOK3 on chromosome 12? It was found to be associated with lupus according to the GWAS catalog...

Thanks for the useful analysis, especially the comments by Trish. I'm also a bit confused by the scoring system. What does it do or indicate? Assuming a higher score means a stronger indication of PEM, then there are a couple of issues. Having more triggers would be a stronger indication of...

Was wondering if TLR7 is important, wouldn't we expect to see differences in SNPs that influence the expression of TLR7? Haven't read the entire thread, so might have missed something.

Have little to add except that it looks really interesting. Made this summary of the results in case it is helpful to anyone. 1) Impressive study from Johns Hopkins researchers. They infected mice with SARS-CoV-2, found that female mice had a stronger immune response and more cognitive...

Yes, it's helpful in this regard. But also a bit disappointing that it then becomes a clash of eminence, and that the more detailed issues with methodology disappear in the background. Got the same impression with the Cochrane review and the Zeraatkar review on Long Covid.

Davenport et al. write: This isn't entirely on point IMHO. The test only took a couple of minutes, so the increasing symptoms and debility that patients experienced during the test should probably not be viewed as PEM. The term PEM is normally used to describe delayed worsening after the...

I think the focus on the 2-day CPET and deconditioning in the Davenport et al. letter is a bit besides the point. It would have been better if the journal had also published the other letter that focused on the problems with the EEfRt. Now Walitt et al. largely ignore these. The only info they...

On our blog, Paolo wrote: This is curious. When using the GenomicRanges and rtracklayer packages in R we only lost about 25.000 variants out of almost 9 million. FUMA/MAGMA report the same in the log file: “25262 positions did not align with the GRCh37 reference.”

Thanks, there's a section at the bottom with updates.

There's also this blog by Paolo Maccalini on the DecodeME results, focusing on the FUMA SNP2GENE analysis, which forestglip explored earlier in this thread. https://paolomaccallini.wordpress.com/2025/10/04/cell-type-analysis-of-decodeme-gwas-data/

Thanks. I misunderstood fine-mapping as a broad term encompassing gene prioritization (some tools and papers give that impression), but will update the text. Agree. If you click on one of the other SNPs with low p-value it does show the LD. Didn't mean to imply that a strong signal must mean...

Here's the social media summary for it: 1) We’ve just published our second instalment on the DecodeME results, this timing zooming in on the genes associated with ME/CFS. 2) The clearest signals point to genes such as CA10, SHISA6, SOX6, LRRC7, and DCC, which are involved in neuronal...

Second blog article on the DecodeME results, this time focusing on genes related to ME/CFS. https://mecfsscience.org/genes-pointing-to-the-brain-decodeme-part-ii/

The outcome measures are hard to interpret because the authors don't report variability or statistical tests.

Just noticed the video already has 170k views!

It depends on how you look at it. The 8 significant SNP signals were not seen before in the same pattern in depression or anxiety. There were however genes such as OLFM4 that are implicated in both depression and ME/CFS, even though the SNP pattern around it is different. In addition, the...