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Thanks :thumbup:

Functional disorders share familial risk with internalizing disorders such as generalized anxiety disorder and depression, So, after the GWAS results the relevance to us of the 'functional' label is...? Functional disorders (FDs) such as fibromyalgia (FM), myalgic encephalomyelitis/chronic...

Could somebody post the full Google Drive link in that tweet.

She stresses psychotherapists’ limits: if biological and social needs were met, little would remain for her discipline to address. Grande gets it. This sounds like an article that would be worth translating in full.

I never said ME is FND, What about CFS? Is that FND? Just so we are clear.

And behave very much like a cult.

And yet the threat of these accusations and their appalling real world consequences continues on to this day. Their words are hollow, insulting, and cruel. And utterly gutless. It is beyond dispute that the profession, in cahoots with government, is completely incapable of facing up to the...

It is arguable that the lack of genes known to be linked to depression and anxiety is evidence in favour of any depression and anxiety being secondary reactive consequences of primary physiopathology, combined with huge secondary losses caused by both the disease itself, and serious...

Pain is one of the major symptoms for me, always has been.

Ask him about assessing treatment outcome by questionnaire, which is the preferred method of the psychosomatic/FND club. He might come to regret opening that can of worms.

This. "...because they are never placed in such a situation." And they make damn sure of it.

I don't know how accurate those two AI statements above are (1, 2), but they seem to me clear and concise, which is always a big plus, if for no other reason than that makes it much easier to spot the limitations and flaws. It demonstrates what I have long thought is the main potential benefit...

It is all marketing. His underlying belief about ME/CFS being a psycho-behavioural problem has not changed one bit, since his first comments on it in the formal literature back in the mid-1980s. Don't listen to what Wessely claims to believe, look at what he actually does, very consistently.

Wessely is just pulling his usual ex cathedra act. It is true because the Great Man said so. Accountability is coming, Sir Simon, and there is nothing you can do to stop it. And you thoroughly deserve it. You have been a deeply malign influence on this world, and have caused immense and...

I strongly suspect that the undiagnosed or misdiagnosed rate, especially among the milder end of the spectrum, is going to be an important confounder in general. Nor would I be surprised if a decent chunk of that 'misdiagnosis' in particular was from wiser and more compassionate clinicians...

And an unnecessary burden.

The only words I want to hear from that man, and his fellow travelers, are 'sorry', and 'I resign'. And at well above the average rate for the general population. The poorly understood illness, which is estimated to affect many millions of people worldwide, is associated with debilitating...

So is an infection triggered neuro-immune condition a broadly correct characterisation of ME/CFS, based on these findings? Maybe it is identifying currently healthy people who have an increased genetic risk of getting ME/CFS. Would be interesting to follow that group for a few decades and see...

Stronger associations would have been nice, and there is the issue of inconsistency across studies to be addressed. But otherwise a very welcome and important step forward, that should help focus research efforts on more productive possibilities. Thank you to all involved. :thumbup...

Thank you, @Simon M. Clear and informative as always. :thumbup: Any idea how expensive, and how much value there is in a full detailed gene map study? Or do we have enough now to start focusing down?