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Background: Orthostatic intolerance syndromes such as Orthostatic Hypotension (OH) and Postural Orthostatic Tachycardia Syndrome (PoTS) are common symptoms seen in post-infection conditions and other neurological conditions with autonomic dysfunction. The 10-min Lean Test (LT) is an objective...

Did the same exercise again for 2025, and it looks like NIH funding for ME/CFS research keeps falling. There's some ambiguity about which projects to include (is it sufficiently about ME/CFS or not?), and we may have missed one, but the overall trend seems clear...

Thanks. Yeah in the r/aliens community, he made this comment:

Only 50 patients from a problematic cohort (which found a prevalence of 2.5%, about 5-10 times as high as similar studies). We have better sources now with DecodeME, so not sure it is worth digging into this.

Someone also pointed out that fibronectin 1 was increased in this paper in the ME/CFS group (red in the graph below). A previous Prusty paper also reported increased plasma fibronectin 1 Preprint - Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1...

Can you tell which one?

They found that ME/CFS patients had higher proportions of plasmacytoid dendritic cells (CD11c− CD123+, bottom right in the figure below). This is the immune cell type known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection as discussed in this thread: (1)...

There is also already a trial of Colchicine for LC, which found null results: Effectiveness of Colchicine for the Treatment of Long COVID: A Randomized Clinical Trial | Rheumatology | JAMA Internal Medicine | JAMA Network

Think the article is available at this link: https://www.nature.com/articles/s41591-025-04083-x.pdf The trial in question is called "STIMULATE-ICP" and will test "ivaroxaban, colchicine, famotidine/loratadine". https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272472 An...

They found lower butyrate, which is consistent with previous studies: Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients: Cell Host & Microbe Deficient butyrate-producing capacity in the gut microbiome is...

Yeah, not really a surprise, the way he romanticized his descriptions and case studies, things that were hard to confirm by others, it already gave the impression that there were many embellishments.

The researchers have a Dutch grant for ME/CFS research: https://www.zonmw.nl/nl/artikel/blog-een-behandeling-op-maat-met-immuunhandtekeningen-voor-mecvs Don't quite understand why this also showed an interferon difference between groups, given that it was mainly meant as a control condition.

Not really, because the co-occurrence of concepts is probably based on the text of the manuscript, not on the actual data. Suppose that several studies found a slight increase in metabolite X, but do not mention it anywhere in their paper, it's only visible in the supplementary data: would the...

Not far, think I didn't manage to do the FINEMAP.

The statistical tests used age as a covariate, but suspect that the data points shown do not take this into account. The HC group had a mean age of 31, and the LC group of 51. They also don't give much info about how the patients were selected. Suspect the study was done on patients in...

This isn't the first time that we've seen questionable papers from this group. See: Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al | Page 4 | Science for ME

The raw data of the experiments, for example, in CSV format. A big problem I see is that almost all studies misrepresent their data in the abstract and text (to make it look like a bigger deal than it is or to promote the authors' favoured theory). So I think machine learning/AI/network...

Seems like a useful commentary. If I understand correctly: - The groups are independent; this wasn't a longitudinal study following the same people over time - Although there were differences between groups, they were relatively modest and still within normal limits - The difference might be...

Thanks for trying this. I gave up because my coding skills are rather amateurish. There was also the issue that I wouldn't be entirely sure if it worked or if I had misapplied it somehow. I was hoping that either researchers would use this in future publications (e.g. the official DecodeME...

Thanks. If I understand correctly, though, your network analysis is based on mentions in abstracts and the text of a publication and not on the actual data of studies?