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  1. Sean

    Trial Report Clinical Improvements Following a Non-Aerobic Therapeutic Exercise in Women with Long COVID, 2025, Miana et al

    Repeating a previous statement or claim, just with different wording, is something that AI generated text frequently does. -------- Participants engaged in a therapeutic exercise program designed to promote correct body alignment and optimal biomechanics And the evidence for patients having...
  2. Sean

    2025: looking back on a year of ME/CFS research

    Negative (null) results are just as important as positive results. The only important questions about a study are 1) is it relevant, and 2) is it well conducted. I would write 250.000 as 250 000. Positive results have a comparable problem if they are false, which they sometimes are. The story...
  3. Sean

    UK: Physios for ME

    And, of course, requires the instruction and oversight by a 'professional expert' to achieve. It just continues the long discredited and very destructive assumption that patients don't know their own body and its limitations, but by some miracle, against all evidence and logic, the experts do...
  4. Sean

    Why is showering so PEM/OI inducing

    Interesting. I tend to move about a bit in the shower, changing from one foot to the other, turning around frequently, etc. Maybe that is an unconscious learned thing to dynamically maintain balance and blood flow.
  5. Sean

    Does symptom perception after negative affect induction differ between physically ill and healthy individuals? ... 2026 Jessen et al

    Symptom perception is highly subjective and shaped by complex biopsychosocial factors. Always good to start with your conclusion. :rolleyes:
  6. Sean

    Why is showering so PEM/OI inducing

    Showers have a price. I often lie down for a bit after one, depending on various factors. OTOH, a hot shower is very good for soothing sore muscles and stimulating blood flow.
  7. Sean

    Fred Rossi - Writings related to ME/CFS

    Good article. Thank you, Fred Rossi.
  8. Sean

    Proxy Praxis: How Surrogate Endpoints Can Speed Drug Development

    Yes, what about relevance, safety, and conflicts of interest?
  9. Sean

    Preprint Distinct Symptom Clusters Reflect Pathophysiological Mechanisms in ME/CFS, 2025, Habermann-Horstmeier et al

    And this, ladies and gentlemen, is why relying on superficial correlations is so dangerous.
  10. Sean

    Hypotheses and Research Directions for ME/CFS

    Any hypothesis must explain the delayed component of PEM. It is a distinct and core feature, and the main clue, I think. It is not fatigue, tiredness, deconditioning, DOMS, etc. It is something different to all those.
  11. Sean

    USA: News from Solve ME

    So what that tells me is, ME/CFS is not a single disease, but it is a disease with different biological subtypes. Maybe. Cancer has a wide range of forms, symptoms and signs, and causes (genetic, chemical, infectious, radiological), and different treatments. But all cancers have one thing in...
  12. Sean

    Healthcare use and costs of functional somatic disorder in Denmark: a population-based cohort study (DanFunD) 2025 Petersen, Fink et al

    Functional somatic disorder (FSD) is a common condition characterised by persistent patterns of physical symptoms that cannot be better explained by other physical or mental conditions. Unless there is a translation issue, then this is a disingenuous rhetorical sleight-of-hand. They are not...
  13. Sean

    ‘There’s nothing wrong with you’: The making of disability through encounters in accessible parking spaces, 2025,Kubenz

    I qualify for a disabled parking permit, but have not taken it up for exactly these reasons. Not going to add another layer of abuse to what I already have to deal with. In a practical sense it doesn't make much difference, for various reasons. But there are occasions when I could benefit from...
  14. Sean

    Do we need a long-term actimeter study of PwME outside of treatment?

    I agree, as long as there are good records of what the patients do so it can be factored in. Should help reveal what helps and what doesn't, among other things. The key is having a large sample size, and doing it for long enough.
  15. Sean

    Do we need a long-term actimeter study of PwME outside of treatment?

    My answer is yes. Two actimeters. One on the dominant hand (wrist), and one on either ankle. Maybe a third on the upper dominant arm, just below the shoulder. Though that may be too impractical for long-term measurement. Using a range of bio-monitors on a large number of patients to measure...
  16. Sean

    Works of fiction where characters have ME/CFS

    Typically, even. At least initially. Something we are all guilty of to some degree. Which is why robust methodology is so important.
  17. Sean

    Somatization, psychological distress, and quality of life across [FM], [IBS], and their comorbid phenotype: ... 2025 Prospero et al

    Fibromyalgia (FM) and irritable bowel syndrome (IBS) are increasingly recognized as disorders involving central sensory processing and gut–brain axis dysregulation, Recognised by whom? Mostly by people who claim these conditions involve central sensory processing and gut-brain dysregulation...
  18. Sean

    Ken Ware - Neurophysics therapy

    Forgot to say that this testing was done more than 25 years after getting sick, which included some periods of being more or less bedridden. If deconditioning was going to show up it should have shown up by that point.
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