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  1. Sean

    What a longevity expert eats in a day—Eric Topol

    Nuts are great foods, one of the healthiest and tastiest and most convenient there is. I could eat them all day. But they are also a trap for the unwary because they are calorie dense due to the high oil content and so easy to consume. If you want to put on weight, start eating nuts. I limit...
  2. Sean

    Supporting people with myalgic encephalomyelitis in primary care, 2025, Chowdhury

    I agree with using and promoting ME/CFS. It is not great, but is the most workable compromise we have for now, all things considered.
  3. Sean

    Supporting people with myalgic encephalomyelitis in primary care, 2025, Chowdhury

    Patients never have. But the initials have been mocked in the distant past by a few as just having a 'look at me disease' kind of thing.
  4. Sean

    Post-COVID Rehabilitation Outcomes: A Comparative Cohort Study, 2025, Prüfer et al.

    And even less effective for the other conditions in the study. -------- There was an average gain on the 6WMT of 50.5m (30-60m) for all conditions, giving absolute outcomes of 531-599m (except for COPD at 455m), and "baseline adjusted" scores for the 6WMT of PC=632.4 m vs ALL=603.4m. But...
  5. Sean

    Grounding in dance movement therapy for people with persistent physical complaints, 2025, Silva et al

    A lot of the psych based 'treatment' is just a combination of that, plus encouraging the patient to simply deny the reality of their situation, a form of self-gaslighting. Distract and deny therapy.
  6. Sean

    Enduring symptoms: A call to immediate action, 2025, Barnes

    Funding these clinics not only wastes money, but causes considerable harm by maintaining the fiction that there are effective treatments available to those patients who really want to be well. And strongly implies, their claims to the contrary notwithstanding, their preferred psycho-behavioural...
  7. Sean

    Characterization of Post-Viral Infection Behaviors […]: Prospective, Observational, Longitudinal Cohort Analyses of Fitbit [& PROs], 2025,Zhang,Unger+

    Our finding that a lower MVPA [moderate-vigorous physical activity] level was associated with more improvements in outcomes in the long-term seems to suggest some benefit from reduced activity. As we have been saying for [checks notes] effing decades. And the earlier patients can implement...
  8. Sean

    Review Comparative efficacy of various exercise therapies for chronic fatigue syndrome: A systematic review and network meta-analysis, 2025, Liao et al.

    We are in the era of just making shit up, where methodological standards are whatever you want them to be.
  9. Sean

    Impact of Prior History of Traumatic Stress on Autonomic and Multi-System Symptoms Following COVID-19 Infection, 2025, Hendrickson et al

    Design Observational, self-report, single time-point online assessment. Stopped there. Saved time.
  10. Sean

    Trial Report Clinical Improvements Following a Non-Aerobic Therapeutic Exercise in Women with Long COVID, 2025, Miana et al

    Repeating a previous statement or claim, just with different wording, is something that AI generated text frequently does. -------- Participants engaged in a therapeutic exercise program designed to promote correct body alignment and optimal biomechanics And the evidence for patients having...
  11. Sean

    2025: looking back on a year of ME/CFS research

    Negative (null) results are just as important as positive results. The only important questions about a study are 1) is it relevant, and 2) is it well conducted. I would write 250.000 as 250 000. Positive results have a comparable problem if they are false, which they sometimes are. The story...
  12. Sean

    UK: Physios for ME

    And, of course, requires the instruction and oversight by a 'professional expert' to achieve. It just continues the long discredited and very destructive assumption that patients don't know their own body and its limitations, but by some miracle, against all evidence and logic, the experts do...
  13. Sean

    Why is showering so PEM/OI inducing

    Interesting. I tend to move about a bit in the shower, changing from one foot to the other, turning around frequently, etc. Maybe that is an unconscious learned thing to dynamically maintain balance and blood flow.
  14. Sean

    Does symptom perception after negative affect induction differ between physically ill and healthy individuals? ... 2026 Jessen et al

    Symptom perception is highly subjective and shaped by complex biopsychosocial factors. Always good to start with your conclusion. :rolleyes:
  15. Sean

    Why is showering so PEM/OI inducing

    Showers have a price. I often lie down for a bit after one, depending on various factors. OTOH, a hot shower is very good for soothing sore muscles and stimulating blood flow.
  16. Sean

    Fred Rossi - Writings related to ME/CFS

    Good article. Thank you, Fred Rossi.
  17. Sean

    Proxy Praxis: How Surrogate Endpoints Can Speed Drug Development

    Yes, what about relevance, safety, and conflicts of interest?
  18. Sean

    Preprint Distinct Symptom Clusters Reflect Pathophysiological Mechanisms in ME/CFS, 2025, Habermann-Horstmeier et al

    And this, ladies and gentlemen, is why relying on superficial correlations is so dangerous.
  19. Sean

    Hypotheses and Research Directions for ME/CFS

    Any hypothesis must explain the delayed component of PEM. It is a distinct and core feature, and the main clue, I think. It is not fatigue, tiredness, deconditioning, DOMS, etc. It is something different to all those.
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