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A pre-announcement announcement. :rolleyes:

You could probably achieve better blinding in tricyclic trials with an anticholinergic antihistamine serving as the placebo but they never do it.

Can’t really maintain blinding in placebo-controlled trials of tricyclics because they have such obvious characteristic side effects (dry mouth, drowsiness).

No because the homeopathic dose prescribed in this trial (10 mg) is 10x lower than what’s needed to achieve an antidepressant effect.

Having a horrible illness is a risk factor for depression. Shocking.

There is actually no reliable evidence that GET cures OI without PEM either. Studies in that area suffer from huge dropout rates and other problems.

I hear you. My EF is shot and I have no working memory. My digit span is like zero.

Can’t read this awful essay as it’s behind a paywall.

Since developing ME/CFS and POTS, I can't hold my breath for even 5 seconds without huge discomfort.

The sheer brazenness of this woman suing Data Colada. This sort of "fake it till you make it" attitude is very much encouraged in organisational psychology / business circles.

As we all know, a subset of patients have disordered breathing which has been a fertile ground for proliferation of psych theories and interventions. This hypothesis paper addresses what it thinks are the causes of hyperventilation from a different angle. Key section: Fig. 2. Putative...

It's the same 5 people flooding journals with the same article rewritten 100 times.

I'm surprised they replied at all, even if it was a non-response response. I can only imagine the chaos behind the scenes.

The descriptions of these projects are quite vague.

Ugh.

Good letter. Seems like a cautious guy. I wish people would stop bombarding him with dumb questions like where they can get tested and let the man work.

Most “journalism” in the UK consists of copy-pasting, maybe slightly paraphrasing, KCL / SMC press releases.

Same here, literally like a switch. I have no idea why Nath is making these reckless statements scaring people. The whole “problem” with ME/CFS diagnosis is that there’s no obvious damage you can point to, hence why most think we’re faking it.

Absolutely. To us it seems easy to diagnose this but the average doctor out there is clueless and quite often hostile.

Definitely. No one starts off talking about cancer by saying it’s real. They only say that about things they regard as not real or at the very least “less than”.