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Wouldn’t that potentially tie in with the idea of generalised sensory mishaps? I’m partially thinking of ORs again here as I was reading up on their functionality and cAMP being involved but presumably it could happen in different places? I guess these are quite, generalised systems, but maybe...

To be fair I suppose the subheading does say “Let’s make this the decade we finally develop treatments for this condition, writes Sonya Chowdhury”. It’s pretty clear to anyone reading this. It’s not a great headline, but how many headlines these days reflect the story? What Sonya has said is...

I wonder about that. Because I’d probably answer no, because sleep does help me. Not sleeping really causes me problems. I would even say I would rather sleep too much than too little. But there’s a goldilocks zone and I also wonder if it’s particularly linked to being awake or asleep at...

I’m not sure I can answer this very well. I can feel ‘worse’ or more groggy and slow after sleeping some more, but did when well too and also know this happens with others without ME/CFS as @EndME mentions. There’s also the usual ‘it depends’ uncertainty. But also my initial answer would just...

Here’s the report, as with the PrecisonLife analysis please take with a pinch of salt, but there may be something interesting for people here. I’m having more difficulty getting my head around this than PrecisionLife and am not sure if mine is the right approach here, although there may be some...

For me, at least these days, I’m always very inactive, but the periods of peeing loads correlate with crashes. Edit: It could be interesting to have some longitudinal studies of some of these hormones, tracked with activity, crashes, etc.

Yeah, cut it short, wipe my head with a wet flannel, that’s about it. I did used to get my mum to wash it. I’d lie with my head over the edge of the bed, face down, with a basin below me and she’d use a jug to pour water over my head, shampoo and rinse. But that’s too much hassle for either or...

It may be wildly off but the experiences of drinking/peeing/etc that many of us talk about is one of the things that made me interested in the idea of involvement of chemoreceptors in the kidneys

Would be nice if more of us could read it but if it’s reasonably sensible and is in the right place to get to the people who need to hear it then I guess that’s a good thing.

Saline solution (salt water basically) has a lot of uses, it’s great stuff. Gargling or rinsing your mouth with salt water is often recommended by dentists after treatment. If you need a cut cleaned up it will often be done with saline wipes. There’s a good overview here of the medical uses...

Thanks @Evergreen and that description of @wabi-sabi is interesting. There was some talk of the multiple sensory stimulation aspect of things like showering in another thread (sound, heat, touch, balance, visual movement, etc)

I used to like dancing and if I could again I would like that too. Is this a ‘nice things are nice’ paper?

My original post stuck to the practical and was more focused on what could be done than the difficulties and what cannot. Partly I suppose because that’s the way I like to share things that may be useful and partly because I assume all severe people know certain things. As so well communicated...

Thanks all, bought a couple of things to try and I will report back!

It didn’t load for me so I missed that treat!

Wasn’t sure where best to post this or how wide the interest would be so piggybacking on this thread. While looking at different tools and APIs I’ve increasingly found MCP servers being provided by organisations, for example: https://www.ebi.ac.uk/ols4/mcp https://string-db.org/help//mcp/ What...

Sonya even gave them the headline in “2025: A breakthrough year for ME, but we must go further” Good article making the argument for investment in research though.

They’re just clusters of genes with similar patterns of tissue expression. I haven’t dug into what their functions are yet. In each chart the bars on the left are the silhouette scores of every gene in every cluster, while the right hand side is the overall score for each cluster as a whole.

Basically yeah. A measure of how close a data point is to others in its cluster compared to those in other clusters. I discuss a bit and give some links in my posts here.

Here’s the silhouette analysis charts of each cluster around the peaks, some reasonable looking clusters which seem to be refined but also others which undergo quite a lot of fragmentation. Not sure what to make of this or where to try the enrichment steps to be most informative (maybe 5, 11 and...