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I'm aiming to get a blog out later in the week and I'm talking to 1 of the researchers this morning. It's onw of the most complex papers I've ever read, so it might take me a while. Briefly, this approach, by a techbio company, uses a novel analytical method on existing genetic data (from the...

This is now sold out - will videos of the sessions be made available in due course?

Sorry to hear that, Andy - hope you make a good recovery from Covid Best - one of the disappointed hordes.

This rather excited opinion piece by psychosocial enthusiasts is founded on getting the maths wrong. Their great "insight" is that the association between MS and EBV is generally weak, and only strong for the 36 cases of MS who were EBV negative when they join the military and 35 subsequently...

It's worth remembering that this is Covid, where severe infection means hospitalised, ICU and sometimes death. Even 'mild' covid is often pretty nasty and might well compare with the illnesses included in the Dubbo study (glandular fever, Ross River Virus and Q fever) I think it would be worth...

Worth bearing in mind that the original analysis (backed up by this new one) found that the only significant predictor of CFS at 6 months was the severity of the initial infection and not psychological factors. I think all the data in the original study came from analysing SPHERE data...

We wouldn’t have either budget or ethical approval for this. But other researchers could apply to recruit from Decode ME participants who have consented to be approached about joining further research studies. research is within also have the genetic data on these participants. That’s one of...

the different figures are because they needed to use different statistical approaches for different sets of data. The hazard ratios for illness severity and mood disturbance are hazard ratios of "recovery" (I know, it's odd) and the data is the number of days for recovery for each patient. They...

Commentary: a (fruitless) search for biopsychosocial gold? In a nutshell: this appears to be an unsuccessful attempt to find biopsychosocial gold by looking to see if neuropeptide Y (which has links to anxiety and stress) is linked to developing CFS after an infection. There is no link, and...

I agree. My understanding is that the reason for most research studies requiring the 50% reduction in function is to give greater certainty of diagnosis. As you say, it might be valuable to study milder cases that won't have the confounding factors associated with long-term chronic illness...

I think this is important work. There are many small studies out there - what we need is to see the big picture. Key findings in test-retest: 21w (95%CI −38 to −4, tau = 9.8) pooled mean decrease in work rate at the anaerobic threshold (four studies). 8.5W (95% CI −15.38 to –1.72) pooled mean...

Thanks to everyone who has replied here or messaged me privately. The feedback and suggestions have been very helpful in deciding what to do next.

On the one hand, this makes sense. There are specialist journals for many illnesses. On the other hand, I wasn't aware there was a problem getting good quality ME papers published. There is also Fatigue: Biomedicine, Health and Behaviour, which is ME-friendly and has people like Lenny Jason and...

It's a very interesting piece. "Yet here’s the kicker: hopelessness is a privilege. If my condition was just a bit more severe, my life would be miserable. If I wasn’t married and didn’t have a supportive family, I would be in penury. If I hadn’t chosen a career path that has some flexibility...

Hi I thinking about seeing an ME/CFS consultant privately these two names came up. Has anyone tried them and if so, can they tell me anything about them? Or any other suggestions (and why?) I can't travel so would need to be by video. Thanks.

My blog on the HLA research: https://mecfsresearchreview.me/2020/04/23/the-best-evidence-yet-that-immune-system-problems-can-cause-me-cfs/ (sorry, don't have the capacity to follow this thread properly but post in case this is relevant.)

Thanks for all your comments and analysis. Compared with prevalence studies, DecodeME requires PEM, as you say, and also requires all participants to have a diagnosis of ME or CFS from a healthcare professional. Clinically diagnosing each case ourselves would have been ideal but would also...

Devereux-Cooke et al., 2022 :)

I think so - if there is a pathway that gets out of balance in ME (the hypothesis), you would expect to see sDNA differences in genes involved in the pathway or in its regulation. From my dodgy memory banks, a quick summary of the NMR vs metabolomics approaches Like all 'omics, metabolomics is...

Very good to hear there are more studies in the pipeline. Am I right in thinking that other metabolomics studies (Lipkin, Hansen, maybe Unutmaz, Naviaux) didn't find increased use of glutamine/ate? Though I note this: