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In the discussion, the authors say "According to our experimental results, ME/CFS blood cells display a unique characteristic in the impedance pattern…" Yes, as they go on to say, it is significantly different from healthy controls. But no one has a problem distinguishing ME patients from...

Have had a quick read through The paper and thought I'd place here before I went to bed. They do claim that the finding is unique to ME/CFS. So those comparisons with sick controls are essential. As I think everyone has pointed out, bigger samples are also needed. Though the Stanford piece...

Both groups use the same method, the Seahorse analyser. as Lisa says, the findings are consistent because the most obvious exclamation for the load oxygen consumption in ME/CFS plasma is increased mitochondrial activity, the same as Fluge found.

Blog preview Something in the blood It is remarkable that four independent groups have now found that a factor in the blood can affect cell metabolism/mitochondria in ME/CFS and transfer the effect to healthy cells. Here is a summary of the provisional findings. Fluge & Mella The first to...

"Something in the blood" Moderator note: Simon's summary of what we know so far about the "something in our blood" has been relocated to this thread, https://www.s4me.info/threads/blog-summary-so-far-of-something-in-the-blood-by-simon-mcgrath.9168/

EDIT: SUMMARY OF LATEST VERSION OF BLOG POSTED INSTEAD Moderator's note: This post and relevant replies have been copied from this point, https://www.s4me.info/threads/nih-accelerating-research-on-me-cfs-meeting-4th-and-5th-april-2019.7745/page-14#post-161538, in the Accelerating Research on...

I have been in touch with Dr Kathy Rowe, the sole author of the study, who was really helpful in providing additional information. Several points she mentioned are worth sharing (with permission): 1. To count as recovered, patients both had to say there were recovered and to specify how long...

Unfortunately, my migraines are getting ever worse and I probably won't be able to return to this thread after this post. Yes, the distinction between remission and recovery is very important. In this case, though, I think most of the results will cover recovery. If you look at the group with...

The Brown, Bell and Jason paper from 2012 is important in relation to the new study as it aims to see if patients who said they were recovered really were or not. They did this by checking if symptoms and function scores were consistent with recovery, and found "that over time many individuals...

Could you tell me where I could find a clip where he says this, please? Thanks

Commentary [Relatively good] long term outcomes for young people with ME/CFS Katherine S Rowe, 2019 apologies that I haven't taken part in this thread - awful migrainesmeans screens are deadly (I read the paper in print, dictated wtih Dragon and a friend cleaned it up for me). This is a...

Brief commentary An interesting approach to studying "neuroinflammation“ yields only one robust finding. Jarred Younger is looking for evidence that would support hypothesis that ME/CFS is driven by low-grade immune activation in the brain. It's an interesting approach using widely-available...

I read this for another purpose and thought I'd post my comments here. It makes sense to explore the value of the huge insurance claims database, with thousands of cases of "CFS" and "ME", But both the symptoms/factors selected by machine learning and the demographics look implausible for...

Here is the key quote from Michael Sharpe, and he has it wrong: The good thing about a prospective study, the design here, is that you look what happens first and then what happens afterwards. Since the immune activation happens first and the fatigue a long time later that’s good evidence that...

The instants rate of 1.6 cases per thousand = 0 .16% new cases per year. That is implausibly hi given that prevalence (two cases) is around 0.2%. So I would agree that this is not measuring ME/CFS, particularly as they didn’t do a proper diagnosis. There I would be extremely interested to see...

Perfectly put. I am concerned about this claim: it would explain how they get such a small P value from the tiny sample, but that P value does not tell you how likely the finding is to hold up in the wider patient population. On the letter is what we need to know. There is another issue. IIRC...

This looks very interesting, but I am eager to see the full text. The P values are astonishing low for such a small sample size (n = 9). For example: “ME/CFS patients had higher entry time (~12%, p<0.0001)” Normally, a mere 12% difference would not lead to such an extreme P value. This...

@RDP Let me echo @Trish's thanks to you for joining the forum and the discussion (it's great to have researchers here) and add my own thanks for the detailed responses to my many questions. I'd like to respond to a few of your points, grouped below into a few themes: Focusing on individual...

Thanks. Perhaps it would help if I summarise my questions here (modified after the helpful feedback, esp from @alex3619 and @Ravn). 1. Biology of causing ME/CFS 1.1 How do kynurenine, serotonin (and NAD?) leads to ME/CFS, particularly given the limited gene expression of IDO 2 (see below)...