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It looks like they used data for controls from a previous study: S4ME From that paper:

I'm not arguing for adopting CPET as an endpoint, but I'm not sure I understand your specific point here. Presumably, a decrease in metrics on day 2 is not analogous to weak grip strength, since the idea is that this is not something seen in deconditioning, so exercise alone should not improve...

Could you say this in a different way? I'm having trouble following.

Identifying interventions and coping strategies to address the psychosocial repercussions of long-COVID: A qualitative interpretive meta-synthesis (QIMS) [Line breaks added] Abstract Long-COVID is a serious public health concern impacting millions of adults and children around the world...

Olfactory Dysfunction and Cognitive Deterioration in Long COVID: Pathomechanisms and Clinical Implications in Development of Alzheimer’s Disease Abstract Complete or partial loss of smell (anosmia), sometimes in association with distorted olfactory perceptions (parosmia), is a common...

Longitudinal Landscape of Long Flu and Long COVID Zheng, Ming [Line breaks added] Abstract Influenza is typically framed as an acute respiratory infection, yet accumulating evidence suggests that—like SARS-CoV-2—it may trigger persistent, multi-organ morbidity consistent with a post-acute...

Graph-Neural-Network-Based Brain Connectivity Analysis for Early Detection of Long-COVID Cognitive Impairments Using MRI/fMRI Dubey, Supriya; Singh, Jitendra; Bhardwaj, Manish [Line breaks added] Abstract Long-term COVID are frequently causing neurological problems that persist for long time...

Could you elaborate on why not? It seems important to know if a drug might have side effects that could break blinding. For example, might nausea clue people in to whether they received the drug?

The most recent change (today) was removing major depression and bipolar disorder from the long list of conditions they're studying.

I didn't see any discussion about this study on the forum, though there are a few mentions of it, for example: It's studying a lot of conditions that they are referring to as "brain inflammation and related neuroinflammatory conditions", and participants can be self-diagnosed. Here's the...

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research Unhide® Project Also Known as The Unhide® Solve Together Unified Platform Brief Summary The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure...

Some posts have been moved to Who is Simon Wessely?.

Identifying potential post-COVID-19 condition among people experiencing homelessness using longitudinal symptom patterns: A prospective cohort study [Line breaks added] Objectives People experiencing homelessness have high SARS-CoV-2 infection and re-infection burden, potentially leading to...

COX17 was one of the 259 core genes identified in this study. COX17 protein levels were also decreased in ME/CFS muscle tissue in the WASF3 study: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome, 2023 Hwang et...

I added the acronym they wanted to make, ACCESS, to the thread title. OutreAch MediCal Care for HousEbound Patients With Post-COVID Syndrome or ME/CFS of Any Cause

OutreAch MediCal Care for HousEbound Patients With Post-COVID Syndrome or ME/CFS of Any Cause (ACCESS) Start of Description "Based on own clinical experience the grant applicants notice a deficit in the current medical care for patients with Post-COVID Syndrome as well as patients with ME/CFS...

For members that are interested in exploring the data from DecodeME, such as to see if certain genes are near significant loci, here is a link to the summary stats on LocusZoom: https://my.locuszoom.org/gwas/894183/ I wasn't sure if I could share it publicly, but Chris Ponting kindly pointed...

Some discussion has been moved to: Deconditioning – relevance and irrelevance

Oh yeah, none of my posts were specifically about the method in the present paper. Just pushing back specifically on saying someone was probably misdiagnosed if we did find a robust rare variant connection. Edit: Which I am now thinking might not have been Utsikt's point anyway.

Honestly, my statement was just based on the abstracts (there's two links btw). It was just to make the point that researchers can and do talk about mixtures of different rare and common variants as being causal for the same disease. Edit: So in answer to your question, I'm not sure of the...