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  1. V.R.T.

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    In her recent talk Michelle James lists OX40 as a PET tracer that is being investigated in ME. In my email I asked if it was her or someone else studying it but I haven't heard back yet. I know I've been a broken record about these tracers lately but it's an interesting connection!
  2. V.R.T.

    CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies, 2024, Huang et al.

    I've now emailed her. Hopefully I hear back. I find this whole tracer business so facinating!
  3. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    So apparantly (repeating myself from another thread here) according to Michelle James' Stanford talk, someone (it wasn't clear which group) is looking at OX40, a CD4 and CD8 T Cell marker, in a PET study. If that can show the bone marrow, perhaps that might give us some clues?
  4. V.R.T.

    CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies, 2024, Huang et al.

    Thank you!
  5. V.R.T.

    Community Symposium on the Molecular Basis of ME/CFS Sept 5 (Stanford/Ron Davis)

    In Michelle James' talk she mentioned - in the list of tracers that various groups have been looking at in ME/CFS - that there is a CD4/CD8 T cell marker called OX40. I don't know if it's her lab or someone else looking at OX40 but I would be very interested to see what the results of that are.
  6. V.R.T.

    CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies, 2024, Huang et al.

    I hadn't thought about the fact it might not necessarily be involved because its high- good point. Ah that sounds like it could be complicated. I drafted an email to Michelle James yesterday but looking now she doesn't seem to have a contact email listed on her Stanford page. I was also...
  7. V.R.T.

    CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies, 2024, Huang et al.

    @MelbME you are running PET studies on ME/CFS patients currently right? Have you considered/would you consider doing a further study using this tracer in order to follow up on your CD38 finding in your study with Jo Cambridge?
  8. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    Perhaps someone should contact Michelle James about this then. If she isn't interested in studying cd38 herself she may be able to advise how best to go about it.
  9. V.R.T.

    United Kingdom: Dr Suzanne O’Sullivan (BPS neurologist)

    A lot of ableists are obsessed with the idea you shouldn't let your disablity define you, and would probably say yes.
  10. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    Just found out that there are cd38 PET tracers - would these be useful for exploring this hypothesis?
  11. V.R.T.

    CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies, 2024, Huang et al.

    Would these tracers be useful for exploring the hypothesis that CD38 is integral to the pathology of ME/CFS?
  12. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    Yes I think I know the exact type of pain you mean. It does often seem to come from inside the bone, if that is possible.
  13. V.R.T.

    MRC/NIHR DecodeME Showcase meeting online and in person Nov 6th

    Yes that really shows a lack of initiative/interest on their part.
  14. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    So if we were convinced the pathology was partly in the bone marrow in ME/CFS, what would the next steps be?
  15. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    Will the DecodeME X chromosome analysis show us if this is the case?
  16. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    That the pathology is in the bone marrow. Perhaps I'm misremembering.
  17. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    Hasn't Prusty been thinking along these lines? Also of course Fluge and Mella must be because bone marrow is where LLPCs live.
  18. V.R.T.

    UK: #JusticeforME fundraising for legal case for UK Government to provide specialist ME/CFS medical care

    I just feel quite worried because this may be a big opportunity to change things. If they are actually successful with this legal challenge and ask for 'specialist care' without being more specific then BACME will just fuck us all over again, and now none of us can complain because 'it's what we...
  19. V.R.T.

    Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Walitt et al

    So much money and patient time and hope was put into this study. The NIH fobbed off patients for years because this study was going to move the field forward and provide answers. And it was such underhanded, patronising bullshit. A deliberate exercise in foot dragging, and then they scold us...
  20. V.R.T.

    UK: #JusticeforME fundraising for legal case for UK Government to provide specialist ME/CFS medical care

    I haven't donated for this precise reason. It isn't that hard to say 'physician led services with specialist nurses and home visits' is it?
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