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Could you elaborate on why not? It seems important to know if a drug might have side effects that could break blinding. For example, might nausea clue people in to whether they received the drug?

The most recent change (today) was removing major depression and bipolar disorder from the long list of conditions they're studying.

I didn't see any discussion about this study on the forum, though there are a few mentions of it, for example: It's studying a lot of conditions that they are referring to as "brain inflammation and related neuroinflammatory conditions", and participants can be self-diagnosed. Here's the...

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research Unhide® Project Also Known as The Unhide® Solve Together Unified Platform Brief Summary The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure...

Some posts have been moved to Who is Simon Wessely?.

Identifying potential post-COVID-19 condition among people experiencing homelessness using longitudinal symptom patterns: A prospective cohort study [Line breaks added] Objectives People experiencing homelessness have high SARS-CoV-2 infection and re-infection burden, potentially leading to...

COX17 was one of the 259 core genes identified in this study. COX17 protein levels were also decreased in ME/CFS muscle tissue in the WASF3 study: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome, 2023 Hwang et...

I added the acronym they wanted to make, ACCESS, to the thread title. OutreAch MediCal Care for HousEbound Patients With Post-COVID Syndrome or ME/CFS of Any Cause

OutreAch MediCal Care for HousEbound Patients With Post-COVID Syndrome or ME/CFS of Any Cause (ACCESS) Start of Description "Based on own clinical experience the grant applicants notice a deficit in the current medical care for patients with Post-COVID Syndrome as well as patients with ME/CFS...

For members that are interested in exploring the data from DecodeME, such as to see if certain genes are near significant loci, here is a link to the summary stats on LocusZoom: https://my.locuszoom.org/gwas/894183/ I wasn't sure if I could share it publicly, but Chris Ponting kindly pointed...

Some discussion has been moved to: Deconditioning – relevance and irrelevance

Oh yeah, none of my posts were specifically about the method in the present paper. Just pushing back specifically on saying someone was probably misdiagnosed if we did find a robust rare variant connection. Edit: Which I am now thinking might not have been Utsikt's point anyway.

Honestly, my statement was just based on the abstracts (there's two links btw). It was just to make the point that researchers can and do talk about mixtures of different rare and common variants as being causal for the same disease. Edit: So in answer to your question, I'm not sure of the...

Some of the references seem to be numbered wrong, since these seem unrelated to the sentences:

Immunological Density Shapes Recovery Trajectories in Long COVID [Line breaks added] Abstract Post-acute sequelae of SARS-CoV-2 infection (Long COVID) frequently persists for months, yet drivers of clinical remission remain incompletely defined. Here we analyzed 97,564 longitudinal PASC...

Just to cover all the bases..were the groups mixed up for all the measurement steps? So the order of testing would be something like HC, HC, ME, HC, ME, ME, HC, ME, ME, HC. Or was any step more like all the HCs go first, then the ME/CFS samples got tested next, even if right after? Just to rule...

That figure is really quite striking. From the stats in the supplementary files, it doesn't look like any other lipid came close. q=.0017 and FC=0.32 for this lipid versus q=0.79 and FC=0.64 for the next most significant one (PE(O-40:5)). I haven't had a chance to really study the methods (and...

I don't know if it's common practice or not - I'm pretty sure I've seen volcano plots where the significance line showed the cutoff of adjusted values (though I also found several that use .05 for the cutoff line just now, like you said). Either way, I don't think you need to show where .05 is...

Discussion about optimal plotting methods has been moved to a new thread: Data visualization

Maybe I'm coming around. This one is kind of aesthetically pleasing and easy to interpret.