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From Wikipedia: IL-1β, in combination with IL-23, induced expression of IL-17, IL-21 and IL-22 by γδ T cells. This induction of expression is in the absence of additional signals. That suggests IL-1β is involved in modulation of autoimmune inflammation [15] A link to gamma delta T cells -...

This is really important and should be campaigned on more. I'd not heard of the phrase extreme phenotype strategy but the principle is common sense and it is shocking that more studies don't focus on the severe. It may be that signals only transiently visible in mild pwME are more often or even...

The sickest thing about ME/CFS is that the illest people are often the people who took all the bullshit advice and declined badly from it. Then they are held up as examples of 'people who didn't take the advice because deep down they don't want to recover'.

If that's the case it could be something interesting.

I have a friend with Hashimotos. She has fatigue and struggles with it but works a full time job, exercises, and has a full social life. That isn't PEM. PEM stopped me from having those things when my ME/CFS was mild. I think a lot of autoimmune fatigue is similar.

What even is long covid if they excluded people with MECFS though? Or is it just pre existing ME?

:banghead::banghead::banghead::banghead:

This is good but we need MPs to stand up and ask them to fund SequenceME. Specifically and repeatedly.

It's mind boggling that they could be getting so many questions in parliament about this for so long and just keep pretending everything is fine in their replies. It reminds me of that meme of the cartoon dog in the burning house.

If only a handful of people recover then the treatments don't work. How can trained professionals not see this? It's cult-like.

TGF-B has been found to be higher in ME/CFS right? Also it says they found HLA DQ was highly expressed in pwLC in the flow cytometry test

Does anyone have any more information about this study? It looks like the summary article is paywalled.

No spoons right now sorry.

What would this mean/entail? I think it was suggested the other day we need a new charity. If reforming AfME like JE has suggested isn't the way to go, then I think that person was right. It would be an unthinkable amount of work but a charity connected to S4ME that funded research that...

Thats fair. It took me a good while of scanning just to find participant numbers because its in the results! Surely that should be front and centre?

My first proper girlfriend in sixth form loved Ricky Gervais and I got dragged to two of his films. Not something I missed when we split up! He's had a few good standup shows, and extras and the office are good, but by and large he's a smug unfunny bully who hides behind an 'I'm just kidding'...

I couldn't say. In terms of benefit, I think the evidence for this JAK drug is a small case study (search the drug name on here to find it). I dont know anything about the other drug. These are serious drugs and only you can make the decision to participate. It depends on your personal...

https://www.sciencedirect.com/science/article/pii/S1359644625000881 Potentially relevant article from last year.

Does this sound plausible? @jnmaciuch @Jonathan Edwards

This looks potentially really interesting, will be interested to see full study.