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  1. Andy

    Advancing regulatory variant effect prediction with AlphaGenome 2026 Avsec et al

    Abstract Deep learning models that predict functional genomic measurements from DNA sequences are powerful tools for deciphering the genetic regulatory code. Existing methods involve a trade-off between input sequence length and prediction resolution, thereby limiting their modality scope and...
  2. Andy

    Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID, 2026, Keat et al.

    One of the other authors, David Price, is part of PRIME.
  3. Andy

    Stigma in functional neurological disorder; a longitudinal study 2026 Mcloughlin et al

    I'm guessing that you mean this tongue in cheek but treating it seriously, yes, there are other people publishing on FND but I tend to find papers authored by Stone and Carson, in particular, as those most problematic, which is why I will post them here.
  4. Andy

    Stigma in functional neurological disorder; a longitudinal study 2026 Mcloughlin et al

    "Introduction Functional Neurological Disorder (FND) presents in varying ways including movement disorders, seizures, cognitive and sensory symptoms [1]. Previously described as a “forgotten” area [2], FND is now increasingly recognised as a valid, treatable condition at the interface of...
  5. Andy

    Stigma in functional neurological disorder; a longitudinal study 2026 Mcloughlin et al

    Authors: Caoimhe Mcloughlin, Neil Ramsay, Lineke Tak, Alan Carson, Jon Stone Highlights This is the first observational study longitudinally exploring stigma in FND and its associated factors. Stigma in FND is high, and does not improve over time. Patients with FND have high levels of...
  6. Andy

    There aren’t any answers, we are looking for them and will support you until we find them

    I have been pondering recently what basic 'positions' about our situation we could get the largest number of patients to support, in order to have the greatest weight of numbers that we can have behind the messaging, and this is a great list. My only suggestion would be to add at the start...
  7. Andy

    A preliminary proof-of-concept trial on the effects of ketamine on fatigue: a randomized crossover trial 2026 Saligan et al

    Abstract Background Fatigue, a prevalent symptom of chronic illness, impacts quality of life. This proof-of-concept, randomized, double-blind, crossover trial assessed the anti-fatigue effects of ketamine (0.5 mg/kg) versus midazolam (0.045 mg/kg), the active comparator. Methods Ten...
  8. Andy

    Methods of Engaging Interest-Holders in Healthcare Evidence Syntheses: A Scoping Review 2026 Todhunter-Brown et al

    ABSTRACT Introduction Engaging interest-holders in health care evidence syntheses may make evidence syntheses more relevant, useful, and accessible. However, the best way(s) to engage interest-holders within the evidence synthesis process remain unknown. A previous scoping review collated 291...
  9. Andy

    Do you have any ideas for topics for PRIME seminars?

    Not that I'm aware currently aware of.
  10. Andy

    Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017–2021 2025 Hinckley et al

    Abstract For some patients who have Lyme disease (LD), nonspecific symptoms can persist after treatment and impair quality of life. Estimating the frequency and duration of such symptoms is challenging. Using commercial insurance claims data from 2017–2021 for enrollees residing in states where...
  11. Andy

    Spontaneous cervical artery dissection is associated with a distinct peripheral immune cell signature 2026 Beuker et al

    Abstract Objectives Despite being a major cause of ischemic stroke in young adults, the biological underpinnings of cervical artery dissection (CeAD) remain poorly defined. Recent data implicate immune activation as a potential contributor. We aimed to determine whether patients with CeAD...
  12. Andy

    Felt Stigma in Youth With Disorders of Gut–Brain Interaction: Implications for Abdominal Pain, Sleep, and Mood 2026 Adetayo et al

    Abstract Children with painful disorders of gut–brain interactions (DGBIs) endorse pain-related stigmatization. However, little is known about how stigma may be associated with pain intensity. Consequently, we conducted a cross-sectional study to identify a potential pathway between felt stigma...
  13. Andy

    Acute effects of interferon-alpha on cellular anabolic and catabolic processes are associated with the development of fatigue... 2025 Periche-Tomas+

    Full title: Acute effects of interferon-alpha on cellular anabolic and catabolic processes are associated with the development of fatigue during Interferon-alpha-based therapy for Hepatitis-C: A preliminary study Authors: Eva Periche-Tomas, Annamaria Cattaneo, Nadia Cattane, Claudia Bone...
  14. Andy

    Do you have any ideas for topics for PRIME seminars?

    PRIME is a project that launched in Oct 2025 (main discussion thread for the project can be found here). Its aim is to build ME/CFS research capacity in the UK through a number of ways, including holding a number of seminars on various relevant topics over the course of the 4 year funded period...
  15. Andy

    Spatiotemporal regulation of energetic charge dictates T cell function 2026 Bousso et al

    Abstract Immune cell functions are dictated by their differentiation state and regulated by transcriptional and epigenetic changes. Immune cell differentiation also controls the preferential metabolic pathways used for energy production. However, whether the energy charge of individual immune...
  16. Andy

    Prevalence of Bodily Distress Syndrome and Prediction of Patient Outcomes: Cohort Study of 3762 Individuals With Persistent Pain 2026 Landmark et al

    ABSTRACT Background Persistent physical symptoms are common and often result in disability and high healthcare use. To capture how such symptoms co-occur, Bodily Distress Syndrome (BDS, also called Functional Somatic Disorders) was developed as an empirically derived construct, in contrast to...
  17. Andy

    Uncovering the genetic architecture of ME/CFS: a precision approach reveals impact of rare monogenic variation, 2025, Birch, Younger et al

    No, it wasn't asked, but as I understand it is theoretically possible to identify relations through their genetic data. For those interested, DecodeME documents, including the two questionnaires, can be found here.
  18. Andy

    Review Gut microbiome remodeling induced by microplastic exposure in humans 2026 Yuan et al

    Abstract The impact of microplastics (MPs) on the diversity and composition of the gut microbiome has been extensively documented in animal studies, but evidence in humans remains limited. Recognizing the potential differences in MP effects between animal and human gut microbiomes, this review...
  19. Andy

    Invisible Illness A History, from Hysteria to Long Covid, 2026, Mendenhall (book)

    Previous articles by Hausmann can be found in this thread https://www.s4me.info/threads/articles-by-elke-hausmann-gp.40011/
  20. Andy

    Prediction bias for physical exertion in chronic fatigue: Evidence from an observational paradigm 2026 Kubis et al

    Highlights A new paradigm reveals central prediction bias for exertion in observed exercise tasks. Participants with chronic fatigue predicting higher exertion levels than controls during exercise observations. RPE bias in chronic fatigue links to fatigue and disability scores but not to...
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