Abstract
Deep learning models that predict functional genomic measurements from DNA sequences are powerful tools for deciphering the genetic regulatory code. Existing methods involve a trade-off between input sequence length and prediction resolution, thereby limiting their modality scope and...
I'm guessing that you mean this tongue in cheek but treating it seriously, yes, there are other people publishing on FND but I tend to find papers authored by Stone and Carson, in particular, as those most problematic, which is why I will post them here.
"Introduction
Functional Neurological Disorder (FND) presents in varying ways including movement disorders, seizures, cognitive and sensory symptoms [1]. Previously described as a “forgotten” area [2], FND is now increasingly recognised as a valid, treatable condition at the interface of...
Authors: Caoimhe Mcloughlin, Neil Ramsay, Lineke Tak, Alan Carson, Jon Stone
Highlights
This is the first observational study longitudinally exploring stigma in FND and its associated factors.
Stigma in FND is high, and does not improve over time.
Patients with FND have high levels of...
I have been pondering recently what basic 'positions' about our situation we could get the largest number of patients to support, in order to have the greatest weight of numbers that we can have behind the messaging, and this is a great list. My only suggestion would be to add at the start...
Abstract
Background
Fatigue, a prevalent symptom of chronic illness, impacts quality of life. This proof-of-concept, randomized, double-blind, crossover trial assessed the anti-fatigue effects of ketamine (0.5 mg/kg) versus midazolam (0.045 mg/kg), the active comparator.
Methods
Ten...
ABSTRACT
Introduction
Engaging interest-holders in health care evidence syntheses may make evidence syntheses more relevant, useful, and accessible. However, the best way(s) to engage interest-holders within the evidence synthesis process remain unknown. A previous scoping review collated 291...
Abstract
For some patients who have Lyme disease (LD), nonspecific symptoms can persist after treatment and impair quality of life. Estimating the frequency and duration of such symptoms is challenging. Using commercial insurance claims data from 2017–2021 for enrollees residing in states where...
Abstract
Objectives
Despite being a major cause of ischemic stroke in young adults, the biological underpinnings of cervical artery dissection (CeAD) remain poorly defined. Recent data implicate immune activation as a potential contributor. We aimed to determine whether patients with CeAD...
Abstract
Children with painful disorders of gut–brain interactions (DGBIs) endorse pain-related stigmatization. However, little is known about how stigma may be associated with pain intensity. Consequently, we conducted a cross-sectional study to identify a potential pathway between felt stigma...
Full title: Acute effects of interferon-alpha on cellular anabolic and catabolic processes are associated with the development of fatigue during Interferon-alpha-based therapy for Hepatitis-C: A preliminary study
Authors:
Eva Periche-Tomas, Annamaria Cattaneo, Nadia Cattane, Claudia Bone...
PRIME is a project that launched in Oct 2025 (main discussion thread for the project can be found here). Its aim is to build ME/CFS research capacity in the UK through a number of ways, including holding a number of seminars on various relevant topics over the course of the 4 year funded period...
Abstract
Immune cell functions are dictated by their differentiation state and regulated by transcriptional and epigenetic changes. Immune cell differentiation also controls the preferential metabolic pathways used for energy production. However, whether the energy charge of individual immune...
ABSTRACT
Background
Persistent physical symptoms are common and often result in disability and high healthcare use. To capture how such symptoms co-occur, Bodily Distress Syndrome (BDS, also called Functional Somatic Disorders) was developed as an empirically derived construct, in contrast to...
No, it wasn't asked, but as I understand it is theoretically possible to identify relations through their genetic data.
For those interested, DecodeME documents, including the two questionnaires, can be found here.
Abstract
The impact of microplastics (MPs) on the diversity and composition of the gut microbiome has been extensively documented in animal studies, but evidence in humans remains limited. Recognizing the potential differences in MP effects between animal and human gut microbiomes, this review...
Highlights
A new paradigm reveals central prediction bias for exertion in observed exercise tasks.
Participants with chronic fatigue predicting higher exertion levels than controls during exercise observations.
RPE bias in chronic fatigue links to fatigue and disability scores but not to...
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