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  1. Snow Leopard

    Pathogens associated with triggering ME/CFS - discussion thread

    There is a huge range of viral upper respirator tract infections. Some of them are dismissed as mere "colds", but some of those "colds" can give you a month long nasty flu-like illness. Epstein-Barr virus can also cause upper respiratory tract infections too (just FYI).
  2. Snow Leopard

    Dr Ron Davis - Updates on ME/CFS research - September 2019 onwards

    To be honest, those mentions make me feel less confident in the the theory, rather than more confident...
  3. Snow Leopard

    Cognitive Behavioural Therapy for chronic fatigue and CFS: outcomes from a specialist clinic in the UK (2020) Adamson, Wessely, Chalder

    Indeed. Generally speaking, if people were really doing much better and pleased, grateful for the therapy, there would be a much higher followup rate. Publishing clinical data like this is only ever "suggestive" quality evidence, but I'm sure this will be cited as strong evidence for the...
  4. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    I'm open to considering splitting. Makes a nice alternative to the lumping of "CFS", "SEID" etc. ;)
  5. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    The "40% of people have innate cellular immunity" is nonsense because it is nonspecific. (and specificity is the fundamental basis of the adaptive immune system!) New York state's confirmed case rate is 2.5%. Claims that seven out of eight people infected have not been tested at all is not...
  6. Snow Leopard

    Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia, da Silveira Alves , 2020

    This isn't a "true association", it's the usual candidate gene association junk. I've never seen a study like this for any disease that wasn't complete trash. (note the only true findings are in rare genetic diseases where they trace the candidate gene heritability with 100% specificity and...
  7. Snow Leopard

    Protocol ReCOVer: A RCT testing the efficacy of CBT for preventing chronic post-infectious fatigue among patients diagnosed with COVID-19.

    The usual "effect", meaning response biases. Notice how they're not considering hours worked as an outcome measure.
  8. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    Another medical doctor who rarely if ever read epidemiological literature before COVID-19 the literature and believes the elite-group think that somehow far more people have been infected than measured. The sensitivity of the serological tests is somewhere around 90%, meaning around 10% of...
  9. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    On this topic, several groups are developing monoclonal antibodies (often treatments combining several), which may be brought to market at around the same time as vaccines.
  10. Snow Leopard

    Effectiveness of an ACT‐based rehabilitation program for the treatment of chronic fatigue: Results from a 12‐months longitudinal study, 2020, Brugnera

    I would have liked to see a scatter plot of hours worked vs change in hours worked, but alas this was not done. I mean it wasn't as if return to work was the primary outcome of the treatment. Oh wait, it was! Hmm...
  11. Snow Leopard

    Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Thapaliya et al. 2020

    I'm still trying to work it out. The diagram is suggesting lower ferric->ferrous conversion (STEAP3), it is implying lower uptake by TfR1 & DMT1, but no data for DMT1 or TfR1 was provided, so this lowered uptake is assumed to be due to imparied vesicle endocytosis. The last diagram implies lower...
  12. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    Impossible to say right now, because the medical authorities haven't bothered to keep track.
  13. Snow Leopard

    Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia, da Silveira Alves , 2020

    More candidate gene association junk. Unless the SNP is highly specific (100% of cases as in rare genetic diseases), I just don't care.
  14. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    On the contrary to the authors claims, an unexpectedly low number (1.6% compared to population norms) of depression/anxiety was associated with an absence of caseness. In fact diagnoses in both groups were below Irish norms, agreeing with your hypothesis of participation bias...
  15. Snow Leopard

    Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Thapaliya et al. 2020

    This study is novel in that the active MRI tasks was the stroop test. The magnitude of the observed effect may suggest that this is a consequence, rather than a cause of the dysfunction in ME. Notably the T1w/T2w artifacts were noted to be in the opposite direction as observed in multiple...
  16. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    As I posted on the SW thread, the incidence numbers were significantly lower than what we've seen from SARS-2 (or EBV for that matter). 227 reported cases for 113,979 influenza diagnoses (though only 13054 cases were laboratory-confirmed).
  17. Snow Leopard

    Fatigue measurement scales

    Yes, there is a total lack of clarity, or blurring of what is actually being measured. Fatigue usually means many different things when it comes to these questionnaires, but those who use them do not care about specificity. Similarly, the measures of "validity" are very superficial (and usually...
  18. Snow Leopard

    Objective assessment of diverse types of MS related fatigue and fatiguability

    The "metacongition" stuff is merely speculation. The authors don't seem to understand, nor care about how peripheral efferents are directly coupled with central drive through the spinal column. No magical (meta) brain interaction is necessary (or likely). The authors are probably confused by...
  19. Snow Leopard

    Massachusetts ME/CFS & FM Association launching Research Club Support Group on Zoom this month

    Has anyone participated in one of these meetings? I'm curious about the level of engagement with the audience / interesting questions being asked?
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