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If it doesn't discuss the key sensory pathways (eg muscle afferents) and effect on spinal nerves and brain (eg central fatigue, a process which can be blocked) then it has zero validity for the claim of discussing "the scientific basis"of fatigue"

The latter latter

I have parasthesias so probably, but never tested. Most of the tests focus on skin biopsies but there are numerous types of SFN that is not covered by that at all.

The 18 genes singled out are mostly associated with the nervous system (both CNS and associated with peripheral nerve disease, injury or recovery), the immune system and mitochondria. eg starting with the first one, ABT1 is a mitochondrial associated gene but is associated with the IGHMBP2...

I get this all the time, due to allergies/histamine issues. A new symptom is a pop, then tinnitus (and ear feels like it's blocked) until I can pop it again, after which the tinnitus goes away.

It's not the only board he's on, it seems like a pattern of going against patient experience and needs. https://transsafety.network/posts/simon-wessely-history-discrediting-sick-disabled-people-bad-news-trans-health-research-priorities/

This can happen due to central fatigue, basically to maintain the same activity you now have to put in more effort, which is also causes a greater respiratory rate and a higher heart rate in turn. Healthy people need to do more intensive activities (jogging/running at intensity levels past the...

Heart rate variability is an extremely non-specific outcome measure and one of the strongest predictors (amongst many poor predictors) for reduced HRV is poorer physical fitness which is strangely absent from this study. edit - and yes, this does read like AI slop.

Less than a minute. And yes, >150 BPM is a high heart rate to sustain in middle aged or older people

The anaerobic threshold is task specific, it is not a fixed HR threshold regardless of task, despite so many people thinking it is just that. Focusing on the HR at the AT during a cycling test is only really relevant to cycling. Some tasks will reach the AT in specific muscles at very low heart...

I'm not sure. The fact is that almost all of the study results tend to show very low maximum heart rates for the VO2Peak suggesting these people are not used to exercising at a high V02 level and are not actually reaching their VO2Max. Poor oxygen extraction (and poor fitness) itself doesn't...

The word "mechanism" is mentioned a lot given there is no known mechanism. I'd argue further that central sensitization is in fact a normal part of healthy nociception - they'd have to demonstrate abnormality of that mechanism as well.

Oh, "transdiagnostic" is another way of disguising a focus mental health diagnoses.

These studies are meaningless without population based cohorts, the results also reflect participation/referral biases.

Can't this simply be due to differences in response biases on the scales/questionnaires rather than an actual underlying effect?

If they aren't bringing any evidence, what is the point of the talk?

I wonder whether the shunting itself is a compensation mechanism for low RAP.

Isn't the increased venous compliance / low systemic vascular resistance also associated blood pooling hence lower filling pressure? Varicose veins are associated with AV shunting for example. https://www.sciencedirect.com/science/article/pii/0741521486904118

The shunting means more motor units are required to achieve VO2Max, which means more effort exerted by patients, especially past the ventilatory threshold which is one of the most common observations on CPETs in patients. I have the same 2 day CPET issues and I did suffer from peripheral...

Note that the problem wasn't that they didn't include women in the trials, the problem is the trial design itself - they didn't consider trialing lower dosages for women. Also note that age makes a huge difference in dosage as well, with elderly people often needing half the dose of some drugs...