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My suspicion is that most cases are non-infectious (being handled by adaptations) and that infection pushes things over the edge. I would expect to see more long COVID cases over a longer term as people's initial adaptations fail. When I look back at my history I see a lot of signs of the...

In conclusion, we show reduced mitochondrial respiration in skeletal muscle, a metabolic tissue that is critical for strength, movement, and metabolism particularly in aging, during the earliest stages of AD-related cognitive decline; and effects that appear to be affected by the commonly used...

Autoantibody helps with Long Covid The German article https://www.fau.de/2021/07/news/medikament-gegen-autoantikoerper-hilft-bei-long-covid/ The paper is most interesting because of microcirculation, plus the use of BC 007, originally a heart related drug, as a treatment...

https://advances.sciencemag.org/content/7/22/eabf0971/tab-article-info https://doi.org/10.1126/sciadv.abf0971 Abstract In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR)...

https://doi.org/10.1016/j.cmet.2021.02.017 "Exercise training positively affects metabolic health through increased mitochondrial oxidative capacity and improved glucose regulation and is the first line of treatment in several metabolic diseases. However, the upper limit of the amount of...

https://www.nature.com/articles/s42255-021-00342-6 "These findings suggest that neonatal ketogenesis protects the energy-producing capacity of mitochondria by preventing the hyperacetylation of mitochondrial proteins."

https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1874134 The news article got me interested because of the reference to "restores mitochondiral energy metabolism" Scientists demonstrated that the strength of elite controllers comes from their energy metabolism within CD8 lymphocytes...

I tried NDL for several months. For many years I've had a foreearm itch that was not relieved by any medication. LDN seeemed to fix that. One the other hand, it seemed to leave me with a numbness. Eventually I just stopped taking it. For me, it is one of many medications that provides a...

I prefer good studies to anecdotal evidence, but here goes... I've been using LDN for several months, ramping up to a 4.5 mg a day dose. I haven't noticed any side effects, even while ramping up. I'd say my general energy level has improved. I am more likely to just make a phone call, rather...

I'd agree that doctors rarely take the big picture view of orthostatic intolerance as "I feel better lying down". If they don't see any heart rate or blood pressure changes they're typically not interested. For years I've noticed that I can be lying down with a very active mind, composing...

I sent Paul Fisher the link, along with a slight apology in case he'd already seen it. It was amazing to get a quick reply along with a thanks for the heads up.

The program at the Chronic and Complex Disease program in Vancouver has an over two year waiting list. It seems to concentrate on having the patients from all of British Columbia travel to the hospital. They seem to run small groups of patients through courses to help them deal with ME/CFS. The...

This was the quote I found most interesting... "Dr. Elrod's team also found that, while it can improve cell survival after heart injury, increased MCUB activity comes at the expense of mitochondrial energy production. "MCUB induction is a compensatory change," explained Dr. Elrod. Just like an...

https://m.medicalxpress.com/news/2019-09-mitochondria-stress.html