Mild cognitive impairment and donepezil impact mitochondrial respiratory capacity in skeletal muscle, 2021, Morris et al

In conclusion, we show reduced mitochondrial respiration in skeletal muscle, a metabolic tissue that is critical for strength, movement, and metabolism particularly in aging, during the earliest stages of AD-related cognitive decline; and effects that appear to be affected by the commonly used AD drug donepezil. RNA sequencing relevaled interesting effects on genes involved in mitochondrial function and muscle metabolism. This work provides additional evidence of systemic mitochondrial dysfunction in MCI and AD.

https://doi.org/10.1093/function/zqab045