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More authors who don't understand that scale responses are not symptoms themselves. They never seem to acknowledge the role of altered cognitions during interventions in inducing increased response biases on scales.

I wonder about this too, usually cognitive activity can have additional physical/orthostatic demands at the same time so there sort of needs to be a control (doing the same activity but without the cognitive demand). But I think there is something there with regards to autonomic symptoms, those...

I don't think there is any direct overlap in terms of pathology (and all the cited evidence in the study is very weak and speculative - generalised claims about neuroinflammation are meaningless), but of course there are always going to be patients whom the conditions co-occur (and they are more...

There is a phenomena known as sympathetic sprouting, post neurological injury, there is coupling of afferent (sensory) nerves with downstream efferent sympathetic nerves. This helps aid neurological recovery but can also lead to altered sensitisation of those nerves. Obviously this requires...

Not in ME/CFS but it doesn't do that much in healthy people - it doesn't actually improve exercise performance. Studies of catecolamine levels in circulation in adults with ME/CFS largely show nothing abnormal. The only exercise study I know of was immediately after (lower adrenaline) and no...

My hypothesis to explain this is dysfunction of the autonomic nervous system too, but I don't think it is any sort of generalised "activation of the sympathetic nervous system at all". I think it is more subtle and to do with specific types of nerves rather than the whole system.

This is Scientific Reports, not Nature proper and yes, peer review quality is mixed across and even within journals.

It's easy when you just deny it.

Classic case of association not being causation.

Agreed. I don't see why there is push-back against changing the name.

I've never met a medical practitioner who understands fatigue at all.

Similar to a few noteworthy people from the UK? ;)

It wasn't terrible in terms of misinformation, it just gives no answer or vague answers, but I didn't find it useful either. The problem is largely garbage in therefore garbage out. These LLMs are great at rearranging words but poor at specific reasoning.

Ugh, real fraud numbers are no where near that high.

Australian Doctors are among the highest paid of all, so of course the Australian doctors are constantly whining on Reddit about how their pay rises aren't well above the rate of inflation (unlike most households who's incomes are going backwards against inflation) and they seem to brigade any...

Several of the speakers at the conference coauthored this: Overlapping conditions in Long COVID at a multisite academic center https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1482917/full Grach first authored: "Diagnosis and Management of Myalgic...

I approve of this kind of spite. :rofl:

The issue might not necessarily be central sensitivity across varying patients, but the key is to probe the system as much as possible rather than continue to propose putative conjecture and never test it.

We're talking about targeted scientific studies on nerve function rather than as a treatment effect though.

The Science daily article is a bit confused. The results are largely unsuprising. They simply associated lower activity of some premotor regions with less compensatory effort during fatiguing activity. The sense of effort is upstream of the motor cortex and is effectively the level of...