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I do not think so. There is Steinsvik’s recently published small study on a subset of patients from the RituxME trial who have functional dyspepsia, which significantly overlaps with gastroparesis in terms of symptoms, but according to the literature only about 30% of patients with FD exhibit...

I had much the same experience with trying to get a NJ tube. The hospital staff — and I was hospitalized at a nutrition department — said it would make my stomach lazy. I would tend to think, too, that the problem of gastrointestinal motility probably extends beyond gastroparesis. I assume the...

This feels surreal to read to me as I found myself in the exact same situation just over a month ago. The hospital staff eventually let me try tube feeding at an angle of 15 degrees (though I lowered it to 10 when they were away), but I couldn’t continue as I didn’t tolerate nasogastric feeding...

There have been a couple of papers on delayed gastric emptying (gastroparesis) in CFS: Burnet, R.B., Chatterton, B.E. Gastric emptying is slow in chronic fatigue syndrome. BMC Gastroenterol 4, 32 (2004). https://doi.org/10.1186/1471-230X-4-32 (Abstract only) Gastric emptying in patients with...

Yet the prevalence of CFS is low in this cohort - 0.24% (102/41802), which is only slightly more than half than the UK Biobank’s 0.42% rate.

There may or may not be a biological link between ME/CFS and psychiatric disorders, but the study was not designed to answer this question. It should have compared the prevalence of anxiety and depression among people who have gone on to be diagnosed with CFS versus those who presented with...

A simpler explanation would be that patients who go on to be diagnosed with CFS are given diagnoses of anxiety or depression beforehand because of their unspecific but disabling symptoms (fatigue, pain etc) that stand in contrast with their routine blood tests showing normal results. This is...

Interestingly, Fycompa is an AMPA receptor antagonist that downregulates glutamate, which is the main excitory neurotransmitter. Perhaps the neurologist(s) who prescribed it to Faraz thought that it would help calm some of the “brain and small fiber neuropathy” related symptoms he mentioned in a...

I wasn’t aware that the university hospital of Lille — in northern France, where most of the authors are based — had a psychosomatic approach to long Covid. So far, it had mostly been pushed by Profs Lemogne and Ranque from Paris. Sad to see.

Perhaps this should prompt some reflection on trials of interventions in other fields that are riddled with biases but achieve the same standard deviation of around 0.3 to 0.4 in favour of the intervention. From the 2008 Cochrane review of CBT for CFS:

Thread in English: Of note, the FDA has issued a black box warning for Fycompa (perampanel): https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202834s011lbl.pdf

It seems to me that even if low dose antidepressants can be effective in the short term (up to a few weeks or months), tolerance gradually builds and renders them ineffective in the long term, unless the dose is increased. The same goes for pregabalin and gabapentin. Unfortunately, clinical...

I can certainly attest to these findings. https://www.s4me.info/threads/digestion-issue-causing-overexertion-and-severe-weight-loss.31676/ It would have been interesting to have the patients undergo a gastric emptying scintigraphy (the gold standard for diagnosing gastroparesis) but it is a...

Looking at Figure 2, it seems that a better title for this article would be “Circulating microRNA expression signatures accurately discriminate fibromyalgia from healthy controls and comorbid conditions”. In terms of statistical significance, patients with ME/CFS have the same relative miRNA...

Trials of masking in one particular setting (e.g. at a hospital or a school) are always bound to be flawed because, even if the participants perfectly adhere to it, they will remove their masks in other settings where transmission is just as high (e.g. at home with children). This confounding...

My understanding was that Myhill has practiced as a naturopath since she was struck off the GMC register and, to my knowledge, this profession is both unlicensed and unregulated in the UK. Is this correct? If so, this suspension won’t affect her business.

I hope it will give me more leverage to ask for a nasojejunal tube. Contrary to the nasogastric one they have placed, this would bypass the stomach by feeding me directly into the small intestine. The medical team has been opposed to it, so I don’t know how it will go. I am in Paris, France...

Thank you all for your kind replies. I have tried the Super digestive enzymes from Now Foods to no avail, and my liver function is being monitored regularly by the hospital team as I am being refed and is fine. The gastric emptying scan showed that I do, in fact, have gastroparesis. The...

I recall that Sanofi either gave a grant to Crawley or is running a study with her at the University of Bristol on detecting Pompe disease in children diagnosed with ME/CFS. Sanofi’s incentive is financial as they sell a very expensive treatment for the disease. There has been at least one case...

When I was 6 months into mild ME, I had to decide between starting a PhD or staying at home with my parents to rest. I chose the former, but I wish I had chosen the latter — it made me fully housebound and I had to stop working a year into my PhD. It is a tough decision due to the serious...