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Explanation of the picture: About the isolated factor: https://twitter.com/BhupeshPrusty/status/1233719655602302982 https://twitter.com/BhupeshPrusty/status/1233722114932428800 About confirming the result with the nanoneedle assay: https://twitter.com/BhupeshPrusty/status/1233682363449847809

I might be wrong but aluminium and neurotoxicity ring a bell in the following publications: Amelioration of aluminum maltolate-induced inflammation and endoplasmic reticulum stress-mediated apoptosis by tannoid principles of Emblica officinalis in neuronal cellular model Dhivya Bharathi, M...

That would be absolutely awesome. I'm pleasantly surprised to see a French neurologist working on ME/CFS in collaboration with Paul Fisher's team...

Agh! I wish they had separated the definitions according to whether PEM is a required criterion. This would have been informative, though I'm not sure many studies have used the IOM, CCC or ICC criteria. Is the Holmes (CDC-1988) definition much different than Fukuda (CDC-1994)? Both list PEM as...

So they would have changed their placebo since the older 2014 study for allergic rhinitis... strange?

There, I've edited all my posts to mention that there was no typo to begin with. Thank you! I wonder why they were switched to. Or rather, I wonder if the placebo-turned-active patients' outcome measure was taken into account: does this not introduce serious bias?

Yes, this is clearly a typo. Should be "placebo", because patients were either assigned active treatment or placebo throughout the whole course of the study (noone swapped groups, see my previous post). ETA: actually, this was not a typo. See Keela's post below. Yes, the placebo device does...

Here is a description of the placebo from a paper by the inventor of the KOS device. Juto, J. E., & Axelsson, M. (2014). Kinetic oscillation stimulation as treatment of non-allergic rhinitis: an RCT study. Acta oto-laryngologica, 134(5), 506–512. https://doi.org/10.3109/00016489.2013.861927...

This is so inspiring to us in France. A massive thank you to the determined German patients who are moving things forward for ME -- we'll do our best to follow suit.

From Yandex Translate, slightly corrected:

A recent article from HSJ on CE: https://www.hsj.co.uk/service-design/exclusive-delayed-spinal-surgery-costs-23m-in-compensation/7024296.article Given the complications caused by cauda equina and the compensation pays mentioned above, the NHS certainly won't stop screening for it. Too risky.

Thought this review might be interesting/in line with Bhupesh Prusty's work on HHV-6 causing mitochondrial damage (fission) via a miRNA mechanism. Open access: https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30018-0 Amy Proal has tweeted about it:

The stupidity of the contradiction between these 2 spokesperson really stands out. From the Google translation of the article, bolding mine: :banghead:

This is a systematic review of studies on HRV in 4 different patient populations: CFS, fibromyalgia, IBS, functional somatic syndromes & somatic symptom disorders. Here's the list of studies they looked at for the CFS group. Anyway, per the authors' paragraph about the limitations of the...

@strategist I have had this symptom 4-5 times since December! It's just crazy, I've been wondering if it indicates a neck issue. Here is how I describe it: At night, I'll sleep ~4h, then wake up and go back to bed. But shortly after falling asleep again, I have this weird "pulsing tinnitus"...

I just don't understand why we can't have actual biomedical research. Why must it always come to personal/commercial interests? Just like the PACE trial, this is money wasted for nothing. The usual culprits are in, Esther Crawley included. Setting up a petition against the study that points out...

That is harrowing. I hope their views have changed over time and they've stopped recommending it; it seems to be the case with Lucinda Bateman? [1]. Though I believe Nancy Klimas was a co-author on a recent paper that mentioned GET in a positive way. [1]...

Thank you for pointing this out, I had no idea. The way the tweet was worded made it appear like the caller was deliberately shut out. Do these clinicians specialize in ME/CFS, or do they even know about PEM and the long-term consequences of forced continuous physical activity in ME/CFS? If...

A ME patient advocate was apparently shut out of the CDC call because she stood up to Dr Unger when she refused to disavow GET+CBT for ME/CFS. She still recommends these.

With N = 5 patients, I can't see how this is anything but PR/advertisement for CellTrend. The study relies on CellTrend's assay for ME/CFS [1, 2]. Harald Heidecke is the CEO of CellTrend and Carmen Scheibenbogen is a co-author of the paper. In 2016, they published a similar study in the same...